Androgen Receptor Score of Expression and its Correlation with Prognosis in Triple Negative Invasive Breast Cancer

Mohamed, Manar Montasser; Muhammad, Muhammad Solaiman; Elzawawy, Ahmed Mostafa; Hassan, Wael Abdou; AbdElmohsen, Soheir; Suliman, Marwa A.

doi:10.21608/scumj.2025.410721.1718

	Androgen Receptor Score of Expression and its Correlation with Prognosis in Triple Negative Invasive Breast Cancer
Suez Canal University Medical Journal
Article 7, Volume 28, Issue 9, September 2025, Pages 60-76 PDF (803.2 K)
Document Type: Original Article
DOI: 10.21608/scumj.2025.410721.1718
Authors
Manar Montasser Mohamed^* ¹; Muhammad Solaiman Muhammad²; Ahmed Mostafa Elzawawy²; Wael Abdou Hassan³; Soheir AbdElmohsen⁴; Marwa A. Suliman²
¹Oncology Department, Suez Canal Authority Hospitals, Ismailia, Egypt
²Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
³Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
⁴Clinical Oncology and Nuclear Medicine Department, Suez Canal University, Ismailia, Egypt
Abstract
Introduction: Androgen receptor (AR) is thought to play a crucial role in determining the prognosis of breast cancer patients. No published research that studied score of AR expression and its impact on prognosis. Aim: to correlate the score of expression of AR with the clinicopathological features of triple negative breast cancer patients. Methods: Retrospective-prospective cohort (historical cohort) study of 30 files of breast cancer patients; classified/stratified and tested for Androgen Receptor score of expression, considering time to tumor progression (TTP) as primary end point, and overall survival (OS) as second end points. Results: with a mean follow-up period of 66 months (about 5.5 years), AR intermediate expression (score5) had the best prognosis in triple negative breast cancer female patients; for both TTP and OS (100% had TTP to the 12^th year and 100% had OS to the 14^th year). Conclusion: Androgen receptor intermediate expression had the best prognosis in triple negative invasive breast cancer female patients. We recommend testing androgen receptors in breast cancer patients whenever feasible; to keep it as a possible target (if positive) in case of failure of the approved lines of treatment.
Keywords
Overall survival; Time to Tumor Progression; Androgen Receptor

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