Serum Level of Cholecalciferol in Cirrhotic Patients and Its Correlation with Liver Cirrhosis stages. | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.414160.4112 | ||
| Authors | ||
| Hisham Mohamed A. Alhafaed Almesouri* 1; Ayman Ramadan Abdelhai2; Marwa Aboshabana Mostafa3; Nevin F. Ibrahim4 | ||
| 1Internal Medicine Department, Faculty of Medicine, Omer Elmokhtar University (Darnah- Libya | ||
| 2Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 3Assistant professor of Clinical pathology Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 4Assistant Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Liver cirrhosis frequently results in vitamin D insufficiency and may worsen morbidity and mortality. Cholecalciferol supports bone health, immunity, and metabolism, and its deficiency is linked to poorer outcomes in persistent liver disease. However, It is still unclear how it relates to infection and the degree of illness in people with cirrhosis. In this investigation, blood 25-hydroxyvitamin D [25(OH)D] levels in patients with liver cirrhosis were measured, and MELD-Na and Child-Pugh scores were used to correlate the levels with the severity of the disease. Methods: 72-cirrhotic patients participated in a cross-sectional study at the Internal Medicine Department, Zagazig University. The electro-chemiluminescence immunoassay was used to assess serum 25-hydroxycholecalciferol [25(OH)D] levels. The severity of liver disease was assessed using the Child-Pugh and MELD scores. Data from imaging, lab, and clinical settings were gathered and examined. Vitamin D level was used to classify patients as adequate, inadequate, or deficient. Results: Vitamin D insufficiency or inadequacy affected 88% of patients. MELD-Na and Child-Pugh scores were found to be strongly inversely linked with amounts of vitamin D. MELD ≥20 patients and those in Child-Pugh Class C had the lowest vitamin D levels. Furthermore, cholecalciferol deficiency was substantially linked to increased levels of bilirubin, INR, AST, and lower hemoglobin, serum albumin, and body mass index levels. Conclusion: Vitamin D insufficiency is highly prevalent in liver cirrhosis patients and is associated with the severity of the condition. Considering that vitamin D may be a biomarker for prognosis. | ||
| Keywords | ||
| Liver cirrhosis; Vitamin D deficiency; 25-hydroxyvitamin D; MELD score; Child-Pugh score | ||
|
Statistics Article View: 8 |
||
