Microneedling for Post-Atrophic Acne Scars: Mechanisms, Indications, and Emerging Combination Therapies | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 September 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/zumj.2025.420015.4150 | ||
| Authors | ||
| Esraa Lotfy Abdellatef Bendary* 1; Hebatallah Mostafa Selim2; Eman Salah3 | ||
| 1MBBCH, Faculty of Medicine, Mansoura University | ||
| 2Lecturer of Dermatology, Venereology & Andrology, Faculty of Medicine, Zagazig University | ||
| 3Professor of Dermatology, Venereology & Andrology, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Acne scarring has been one of the most distressing skin problems with a severe negative impact on quality of life and self-esteem. Traditional monotherapy often results in suboptimal outcomes, especially in managing atrophic scars such as rolling, boxcar, and icepick types. Initially, microneedling was introduced as a flexible minimally invasive procedure that causes controlled dermal injury to induce skin remodeling and production of collagen. It has gained widespread popularity over the past decade because of its cheapness, safety profile, and effectiveness in treating scars of all skin types with almost no downtime. lately, combining microneedling with topical agents, lasers, platelet-rich plasma, and other techniques has been used in a wide scale to enhance clinical efficacy. This review provides an updated view of microneedling in dermatology, with a particular focus on its role in the treatment of acne scars. It also outlines the mechanism of action, the types of devices available, techniques of treatment, and the common side effects. Additionally, the article explore evidence supporting the combination of microneedling with topical agents such as adapalene and trichloroacetic acid (TCA), that may enhance therapeutic response and thereby augment skin remodeling. Conclusion: Microneedling is considered a feasible and effective procedure for the treatment of acne scars. Its clinical benefits may be enhanced by combination with agents such as chemical peels and retinoids, which minimize scar visibility and promote collagen production. Hence, knowledge of its mechanism of action, safety, and evidence-based combinations is necessary for achieving optimal results in clinical dermatology. | ||
| Keywords | ||
| Microneedling; Post Acne Scars; Combination Therapies | ||
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