Full Factorial Design, Optimization, and In-vitro Evaluation Iflogia spicata Loaded Nanosuspension for Solubility Enhancement | ||
| Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 September 2025 | ||
| Document Type: Research articles | ||
| DOI: 10.21608/jpsdm.2025.416489.1039 | ||
| Authors | ||
| Radwa M.A. Abd-Elal* 1; Nahla Sameh Tolba2 | ||
| 1Pharmaceutics and Drug Manufacturing Department, Faculty of Pharmacy, Modern University for Technology & Information (MTI), Maadi, Cairo, Egypt | ||
| 2Department of Pharmaceutics, Faculty of Pharmacy, Sadat City University, Sadat City, Egypt. | ||
| Abstract | ||
| Objective: to develop and optimize Iflogia spicata extract loaded nanosuspension; using full factorial design and to assess in-vitro physicochemical characteristics. Methods: A general factorial design (21×31) was generated by Design-Expert® software (version 13), where two factors with different levels were studied (stabilizer concentration ranged from 1-3 % and stabilizer type, such as tween 80 (T80) and sodium deoxycholate (SDC)). nanosuspension formulations were prepared by solvent precipitation technique and evaluated for their particle size (PS), polydispersity index (PDI), and zeta potential (ZP). After optimization, the in-vitro release was performed, followed by the morphological analysis of the optimized preparation with transmission electron microscopy. Results: The factorial model revealed a significant effect of the studied factors on PS, PDI and ZP. Increasing the stabilizer concentration from 1 to 3 % resulted in a decrease in PS and PDI with an increase in ZP with SDC Conclusion: Design-Expert guided optimization efficiently yielded stable Iflogia-spicata nanosuspensions with favorable size distribution and encapsulation. These nanosuspensions demonstrated controlled release and promising in-vitro performance, supporting further preclinical evaluation. | ||
| Keywords | ||
| Factorial design; Nanosuspension; Optimization; In-vitro release | ||
|
Statistics Article View: 5 |
||
