Study of the Association of Some Blood and Urine Markers in Diagnosing in Pediatric Systemic Lupus Erythematous. | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 4, December 2025, Pages 1-7 PDF (783.82 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjcc.2025.418916.1025 | ||
| Authors | ||
| Nourhan Mohamed Elhalaby* 1; OmAli Y Elkhawaga2; dram refaey3; dalia tawfick4 | ||
| 1Chemistry, Science, Mansoura, Egypt | ||
| 2Chemistry Department, Faculty of Science, Mansoura University, Mansoura | ||
| 3Mansoura University, Professor of Pediatrics Faculty of Medicine - Mansoura University | ||
| 4Fellow of Biochemistry and Medical Analysis, Ph.D. from Faculty of Science, Children`s Hospital- Mansoura University | ||
| Abstract | ||
| Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that may present in pediatric cohorts, frequently resulting in considerable morbidity. Identifying dependable biomarkers for diagnosis is essential for efficient management. The objective of this study was to examine the link of some laboratory parameters in the diagnosis of juvenile SLE. The study encompassed children aged 5 to 18 years diagnosed with SLE based on the Systemic Lupus International Collaborating Clinics (SLICC) criteria, as well as healthy controls matched for age and sex. Clinical assessments and demographic information were gathered, and a blood and urinary parameters were analyzed. No statistically significant variations were seen in sex distribution (p = 0.346) or age (p = 0.867) between SLE patients and controls. The average age of SLE patients was 14.4 years, with a majority of females (78.7%). Clinical manifestations comprised fever and malar rash (61.7%), bone discomfort (55.3%), and alopecia (40.4%). Hematological study indicated reduced hemoglobin and leukocyte counts (both p < 0.001), although platelet counts exhibited no significant variation (p = 0.773). Urinalysis revealed elevated amounts of erythrocytes, leukocytes, and proteinuria in patients with SLE, with 34% demonstrating differing degrees of proteinuria (p < 0.001). The findings emphasize the significance of particular blood and urine markers in diagnosing juvenile SLE, indicating the necessity for continued study to enhance diagnostic criteria and optimize patient outcomes. | ||
| Keywords | ||
| Pediatric autoimmune disease; Blood proteins; Hematological analysis; Urinary markers; Autoimmune disorders | ||
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