Eco-Friendly Synthesis of Nanocrystalline Hydroxyapatite Bioceramic from a Natural Waste Source: Bovine Bone | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 4, December 2025, Pages 8-15 PDF (1019.45 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjcc.2025.421687.1028 | ||
| Authors | ||
| Ayda Adel Mohamed* 1; Amr M Abelghany2; Dalia M Ayad3; Magdy Y Abdelaal4 | ||
| 1Faculty of Pharmacy, Horus University, New Damietta, Egypt | ||
| 2national research center | ||
| 3Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| 4Chemistry Department, Faculty of Science, Mansoura University | ||
| Abstract | ||
| The escalating demand for sustainable biomaterials has driven research into valorizing natural waste sources. This study presents an eco-friendly synthesis route for producing nanocrystalline hydroxyapatite (nHA) from bovine bone waste, a plentiful and underutilized byproduct. The process involved cleaning, drying, and calcining the bone at 1000C for 4 hours in ambient air, followed by ball milling to produce a fine powder. The synthesized bioceramic was thoroughly characterized using Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDAX). The results confirmed the formation of a highly crystalline, phase-pure hydroxyapatite with a carbonate substitution characteristic of bone-derived apatite. XRD analysis, supported by the Scherrer equation, and TEM imaging revealed a nanocrystalline structure with an average crystallite/particle size of ~30 nm and a spherical morphology. The Ca/P atomic ratio of 1.77, determined by EDAX, was close to the theoretical stoichiometric value for HA. This work demonstrates a simple, green method to transform biological waste into a high-value nanocrystalline bioceramic with superior properties, making it a promising candidate for advanced biomedical applications such as bone grafts, implants, and drug delivery systems. | ||
| Keywords | ||
| Hydroxyapatite; Bovine Bone; Bioceramic; Eco-friendly Synthesis; Waste Valorization | ||
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