High Voltage Pulsed Current versus Negative Pressure Therapy in Chronic Venous Ulcers Healing: A Narrative Review | ||
| The Egyptian Journal of Hospital Medicine | ||
| Volume 100, Issue 1, July 2025, Pages 4307-4312 PDF (457.48 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2025.453494 | ||
| Abstract | ||
| Chronic venous ulcers (CVUs) are a prevalent and debilitating condition resulting from chronic venous insufficiency, characterized by prolonged healing, high recurrence, and significant healthcare burden. This narrative review explores two advanced therapeutic modalities; High Voltage Pulsed Current (HVPC) and Negative Pressure Wound Therapy (NPWT) that have shown promise in enhancing CVU healing. HVPC employs electrical stimulation to promote cellular migration, angiogenesis, and antimicrobial effects, while NPWT utilizes subatmospheric pressure to facilitate wound contraction, exudate removal, and tissue regeneration. The review outlines the pathophysiology of CVUs, details the mechanisms and clinical applications of both therapies, and critically evaluates existing evidence regarding their efficacy. Although both modalities demonstrate superiority over conventional care, direct comparative studies are limited, making definitive conclusions about their relative effectiveness challenging. HVPC is advantageous for non-exudative, stagnant wounds requiring cellular stimulation, whereas NPWT is preferred for large, exudative wounds needing rapid granulation and fluid management. The review also highlights the potential for combined or sequential use of these therapies and underscores the need for standardized protocols, cost-effectiveness analyses, and patient-centered outcomes in future research. By addressing current gaps, clinicians can better tailor treatment strategies to individual patient needs, ultimately improving healing outcomes and quality of life for those with CVUs. | ||
| Keywords | ||
| Chronic venous ulcers; High Voltage Pulsed Current; Negative Pressure Wound Therapy; Wound healing; Electrotherapy | ||
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