Predictors of Short Term Outcome of Hospitalized Patients with Covid-19 Disease | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.415026.4120 | ||
| Authors | ||
| Ekhlas Mohamed El-Sayed1; Abdel-Fattah Hassan Frere1; Nader Talaat Qandil1; Amira Ali Mohamed Osman* 2; Ayman El Sayed Mohamed Tantawy3 | ||
| 1Professor of Cardiology, Faculty of Medicine, Zagazig University | ||
| 2MBBCH, Faculty of Medicine, Zagazig University | ||
| 3Assistant Professor of Cardiology Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: The 2019 coronavirus disease (COVID-19) can affect several organ systems, including the cardiovascular system, and has varying clinical severity.Therefore, this study focused on cardiovascular injury and disease severity in order to forecast the short-term outcomes of hospitalized COVID-19 patients. using clinical, laboratory, and electrocardiographic parameter. Method: A prospective cohort study was conducted at AL-Ahrar Teaching Hospital and the Cardiology Department of Zagazig University Hospitals in Zagazig, Egypt. A total of 133 hospitalized patients with confirmed COVID-19 were enrolled. Patients were classified according to the presence or absence of cardiac injury based on clinical, laboratory, and ECG criteria. Clinical characteristics, comorbidities, laboratory findings, and ECG parameters were compared between groups. Logistic regression and ROC curve analyses were applied to identify independent predictors of cardiac injury and COVID-19 severity. Results: Among 133 hospitalized patients with COVID-19, cardiac injury occurred in 33.8%. Patients with cardiac injury were older, more frequently male, and had higher CHA₂DS₂-VA scores, elevated AST, creatinine, D-dimer, and INR levels. Logistic regression identified CHA₂DS₂-VA score, elevated AST, and high D-dimer as independent predictors of cardiac injury. The CHA₂DS₂-VA score also independently predicted critical illness (AUC 0.808, cutoff ≥3). Lymphocyte percentage ≤11.25% was associated with critical COVID-19 (AUC 0.714).Conclusion Simple clinical, laboratory, and ECG parameters particularly the CHA₂DS₂-VA score is useful for risk assessment at an early stage in hospitalized COVID-19 patients | ||
| Keywords | ||
| COVID-19; Cardiac Injury; CHA₂DS₂-VA score; disease severity | ||
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