OPTIC NERVE, PERIPAPILLARY AND MACULAR MICROVASCULATURE IN PRIMARY OPEN-ANGLE GLAUCOMA PATIENTS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY | ||
ALEXMED ePosters | ||
Volume 7, Issue 3, July 2025, Pages 59-60 | ||
Document Type: Preliminary preprint short reports of original research | ||
DOI: 10.21608/alexpo.2025.423274.2268 | ||
Authors | ||
Mohamed Saad Morsy1; Mahmoud Alaa Abuhussein2; Nada Medhat Gaballah1; Ahmed Mamdouh Mohamed Farag* 1 | ||
1Department of Ophthalmology, Faculty of Medicine, Alexandria University | ||
2Department of Ophthalmology, Faculty of Medicine, Alexandria University. | ||
Abstract | ||
Glaucoma represents a major global cause of irreversible blindness, characterized by progressive retinal ganglion cell loss and optic nerve head (ONH) damage. Primary open-angle glaucoma (POAG), comprising 90–95% of cases, demonstrates increased prevalence among African American, Latino, and Middle Eastern populations, with positive family history and systemic comorbidities (e.g., diabetes, cardiovascular disease) conferring additional risk. While elevated intraocular pressure (IOP) remains the principal modifiable risk factor, glaucomatous damage may also occur in normotensive individuals, with central corneal thickness identified as an independent susceptibility parameter. Current pathophysiological hypotheses emphasize mechanical stress at the ONH and vascular dysregulation, though both mechanisms likely contribute. Clinically, disease progression is insidious, with optic disc cupping and peripheral visual field loss manifesting only in advanced stages. Comprehensive evaluation requires multimodal assessment, including tonometry, gonioscopy, optic nerve imaging, retinal nerve fiber layer (RNFL) analysis, and perimetry. Recent advances in optical coherence tomography (OCT) and OCT angiography (OCTA) provide quantitative biomarkers, enhancing early detection, progression monitoring, and risk stratification in POAG management. AIM: The aim of this study was to evaluate the ONH, peripapillary area, and macular microvasculature in POAG patients and normal individuals using OCTA. | ||
Keywords | ||
POAG; OCTA; OPTIC NERVE | ||
Supplementary Files
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