Moringa Oleifera Protective Effect Against DNA Damage from Hydroxychloroquine | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 November 2025 PDF (852.38 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.402074.1247 | ||
| Authors | ||
| Wafaa Younes Mohammed* 1; Waleed S. Koko2 | ||
| 1Department of Medical Radiology, Faculty of Medical Technology, Sabha University, Libya | ||
| 2Department of Biology, College of Science, Qassim University, Buraydah 51452, Saudi Arabia | ||
| Abstract | ||
| Background: The objective of this research was to investigate whether powdered Moringa oleifera leaves could offer protection to genetic material from hydroxychloroquine-induced damage in Male albino rats. They were given dry Moringa leaf powder with lunch for three weeks. Additionally, they were administered hydroxychloroquine treatment at various doses every day for five days. Results: The data indicate the presence of malondialdehyde (MDA) in serum. Liver DNA damage was examined using the Comet test and (SCGE) techniques in addition to assessing the superoxide dismutase (SOD) enzyme. MDA increased while SOD dropped otherwise. After the administration of powdered Moringa oleifera leaf, the activity of antioxidant factors was raised, and the MDA level decreased. It can be inferred from these findings that hydroxychloroquine is genotoxic at the dosages utilized, and the liver is a major target organ. In addition to exhibiting a protective role against HCQ-induced DNA damage, M. oleifera demonstrated slight genetic alterations. Level of lipid peroxide (MDA): The HCQ groups exhibited a substantial increase in lipid peroxide (malondialdehyde) activity when compared to the normal group. Antioxidants (SOD): It was discovered that the HCQ groups had markedly reduced superoxide dismutase (SOD) activity than the control group. Enzyme activity, however, was notably elevated in the M. oleifera-treated groups (P = 0.001). | ||
| Keywords | ||
| Key wards: Moringa oleifera; DNA; antioxidant; Hydroxychloroquine | ||
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