Histological assessment of deproteinized bovine bone-bone marrow aspirate versus deproteinized bovine bone alone for guided sinus floor augmentation. A randomized clinical trial. | ||
| Egyptian Dental Journal | ||
| Volume 71, Issue 4 - Serial Number 2, October 2025, Pages 2977-2988 PDF (1.84 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2025.405606.3559 | ||
| Authors | ||
| Hamed Elsayed Abdou1; Walaa Kadry* 2; Israa Ahmed Radwan3; Maha Hakam4 | ||
| 1Principal researcher at Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||
| 2Associate professor at oral and maxillofacial surgery department, faculty of dentistry, Cairo university, Cairo, Egypt | ||
| 3Associate Professor at department of Oral Biology, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||
| 4Professor at department of oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Purpose: To histologically and radiographically compare the newly formed bone (NFB) yielded following sinus floor augmentation using bone marrow aspirate concentrate (BMAC) loaded on bovine bone graft versus bovine bone graft. Methods: The current randomized clinical trial included ten patients with maxillary posterior atrophy who were presented at outpatient’s clinic of the faculty of dentistry, Cairo university. NFB was histologically assessed 4 months following sinus augmentation using BMAC/ deproteinized bovine bone (DBB) (study) versus DBB graft (control). Covariates included residual ridge height, age and sex. At second stage surgery (after 4 months) core biopsies were harvested and submitted for histologic analysis. Results: The sample included 10 eligible patients with mean age of 46.8 years. Both groups showed thin irregular bone trabculae with intervening wide bone marrow spaces, areas of woven bone and material remnants were observed. Higher magnification revealed a high inflammatory cell infiltration in contol group). Moreover, radiographic bone height on CBCT for the study group (13.34±2.76) was higher than that of the control group (10.10±2.46) after 4 months (p>0.05). Conclusions: BMAC /DBB yielded comparable bone gain to the control group. BMAC utilization for sinus floor augmentation supported healing and maintained the grafted sinus height. | ||
| Keywords | ||
| Sinus floor elevation; lateral approach; bone marrow aspirate; histological | ||
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