Assessment of injectable platelet-rich fibrin with hyaluronic acid versus Hyaluronic acid in management of temporomandibular joint internal derangement. (A randomized clinical trial) | ||
| Egyptian Dental Journal | ||
| Volume 71, Issue 4 - Serial Number 2, October 2025, Pages 2997-3006 PDF (792.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2025.412992.3584 | ||
| Authors | ||
| baghdad mohammed al-hage* 1; Walaa Kadry2; Hassan Abdel-Ghany3 | ||
| 1Principal rresearcher at Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||
| 2Associate Professor at department of oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||
| 3Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||
| Abstract | ||
| Objectives : To assess the effectiveness of injectable platelet rich fibrin (I-PRF) / Hyalronic acid (HA) versus HA injection following arthrocentesis in management of TMJ internal derangement. Materials and methods: A randomized controlled clinical trial of thirty patients with TMJ internal derangement were included according to the eligible criteria, and equally divided into three groups: arthrocentesis (Comparator 1), arthrocentesis with HA injection (Comparator 2), and arthrocentesis with HA and I-PRF injection (study). All groups were assessed clinically in terms of pain intensity ( 10 point -visual analogue scale/VAS). Pain score was recorded preoperatively and postoperatively ( 1 week, 1 month, and 3 months). Results: There was a significant reduction in VAS scores for pain intensity across all groups over time (p<0.001).. However, the arthrocentesis alone group showed the most pronounced reduction in pain scores compared to the other two groups. Conclusions: arthrocentesis is an effective treatment approach for temporomandibular joint internal derangement. The addition of HA or I-PRF+HA did not seem to provide a significant added benefit in terms of pain reduction over 3 months. Clinical Relevance: The results suggest that arthrocentesis alone may be a sufficient treatment approach for some patients. | ||
| Keywords | ||
| injectable platelet-rich fibrin; hyaluronic acid; internal derangement; temporomandibular joint; arthrocentesis | ||
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