The association between Interleukin-37 and Allergic rhinitis and its severity | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 1-10 PDF (928.14 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.350473.1441 | ||
| Authors | ||
| waleed Salah eldin Ahmed* 1; Hany Samir Mostafa1; Mohammad Mamdouh Ibrahim2; Omayma O. Abdelaleem3 | ||
| 1ENT , Faculty of medicine ,fayoum university | ||
| 2Department of Otorhinolaryngology-Faculty of Medicine - Fayoum University. | ||
| 3Medical Biochemistry and Molecular Biology - Fayoum university- Fayoum | ||
| Abstract | ||
| Over the last 20 years, the pathogenesis of AR has been widely investigated and the majority of studies have focused on pro inflammatory cytokines. However, anti-inflammatory cytokines in AR have received less attention. Interleukin (IL)-37, a novel member of the IL-1 family and originally termed IL-1F7, has been shown to be a natural suppressor of innate immunity and inflammatory responses. Various normal immune and non-immune cells and tissues express IL-37 including, stimulated B cells, natural killer cells, monocytes, epithelial cells, skin keratinocytes, thymus, lymph nodes, lung and bone marrow .Regarding this point, IL-37 has been considered a key player in a variety of inflammatory and autoimmune diseases ( for instance, inflammatory respiratory diseases, inflammatory bowel diseases, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriasis and multiple sclerosis ) , and studies have shown dysregulated expression of IL-37 under these conditions. The Aim of This Study is to assess the association between interleukin 37 and allergic rhinitis and its severity. This study investigated the relationship between IL-37 levels and various health factors among participants. The results demonstrated significant differences in IL-37 levels between cases and controls, both in blood and after nasal lavage, suggesting potential role of IL-37 as anti-inflammatory cytokine in development of allergic rhinitis disease and its severity | ||
| Keywords | ||
| allergic rhinitis; cytokines; IL-37; marker | ||
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