Assessment of serum interleukins in acne vulgaris... | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 43-54 PDF (720.99 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.342044.1430 | ||
| Authors | ||
| Salwa Mohamed Mahmoud* 1; Nesreen Mohamed Aboraia2; Olfat Gamil Shaker3; Shereen Adel Ali1 | ||
| 1Dermatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| 2dermatology department fayoun university | ||
| 3Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo | ||
| Abstract | ||
| Introduction: Acne vulgaris (AV) is a chronic inflammatory skin disorder characterized by an interplay of hyperkeratinization, sebaceous gland activity, microbial colonization, and immune dysregulation. Among the many mediators implicated, interleukin (IL)17 and IL 6 have emerged as key players, particularly in driving the chronic inflammation characteristic of more severe acne. Aim of the study: To determine the relationship among levels of ILs 17 and 6 in the serum of individuals with AV. Subjects and Methods: We searched Cochrane, Web of Science, PubMed, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: (‘’ IL-6’’ OR ‘’ interleukin-6’’) AND (‘’ interleukin-17’’ OR ‘’ IL-17’’) AND (‘’ Acne ‘’ OR ‘’ Vulgaris ‘’ OR ‘’ dermatological diseases ‘’). Quality evaluation of the involved studies was assessed regarding to Cochrane’s risk of bias tool. Results: we found that patients showed significantly higher serum ILs 17 and 6 levels than healthy individuals (P < 0.001). Additionally, significantly higher levels of ILs 17 and 6 in the serum were detected in individuals with severe AV lesions than those with moderate and mild lesions (P < 0.001). Conclusions: ILs 17 and 6 have a central role in the pathogenesis of AV by driving neutrophil recruitment, amplifying inflammation, and contributing to tissue damage and scarring. Elevated levels of ILs 17 and 6, systemically in serum, correlate with disease severity and resistance to standard treatments. | ||
| Keywords | ||
| Acne vulgaris; interleukin-6; interleukin-17; dermatological diseases; marker | ||
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