The Association of D-Dimer with COVID-19 | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 175-189 PDF (914.8 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.345364.1433 | ||
| Authors | ||
| Reem Amgad Mohamed* 1; Shahira El shafie 1; Fadwa Abd elreheem1; Doaa Younis1; Rasha Hussein2 | ||
| 1Clinical pathology department Fayoum faculty of medicine, Fayoum, Egypt | ||
| 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Abstract: Background: To monitor, prognosis, and formulate treatment algorithms for COVID-19, it is essential to identify severe infection parameters. Objectives: Using D-dimer levels to measure COVID-19 severity, this study aims to investigate the association between severity and D-dimer levels. Methods: The review included eight papers that fulfilled the inclusion criteria of patients with an association of D-dimer with COVID-19 who were COVID-19 individuals and were free from cancer, pregnancy, hematologic malignancy, acute coronary syndrome, chronic liver disease, or surgery. Nevertheless, the quality of the studies that were included was generally satisfactory. Results: This study examined the association between COVID-19 and D-dimer levels in affected patients. Eight studies were incorporated, encompassing a total of 2,916 participants. The findings indicated a notable positive relationship between COVID-19 and D-dimer levels in affected patients. This indicates that D-Dimer levels could serve as a valuable indicator for evaluating SARS-CoV-2 in these individuals. Conclusion: In severe cases of COVID-19, elevated D-dimer levels are associated with the disease. COVID-19 patients may exhibit these laboratory markers, indicating deteriorating health and unfavorable outcomes. However, due to variations in study designs and patient characteristics, further research is needed to establish standardized thresholds and refine treatment approaches. Integrating D-dimer measurements with other biomarkers and clinical evaluations can improve early detection of high-risk patients and optimize therapeutic strategies. | ||
| Keywords | ||
| Keywords: Coronavirus-2; Severe Acute Respiratory Syndrome; D-dimer | ||
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