The Association of D-Dimer with COVID-19 | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 175-189 PDF (914.8 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.345364.1433 | ||
| Authors | ||
| Reem Amgad Mohamed* 1; Shahira El shafie2; fadwa abd elreheem3; doaa younis4; Rasha Hussein5 | ||
| 1Clinical pathology fayoum university el fayoum | ||
| 2clinical and chemical pathology Department, faculty of Medicine, Fayoum University, El Fayoum, Egypt | ||
| 3clinical and chemical pathology department,faculty of medicine ,fayoum,egypt. | ||
| 4clinical and chemical pathology,faculty of medicine,fayoum university,el fayoum,egypt | ||
| 5Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Background: In order to monitor, prognosis, and formulate treatment algorithms for COVID-19, it is essential to identify severe infection parameters. Objectives: Using D-dimer levels to measure COVID-19 severity, this study aims to investigate the relationship between D-dimer levels and severity. Methods: The study was conducted in alignment with the established guidelines for meta-analyses and systematic reviews. The systematic search utilized ScienceDirect and MEDLINE/PubMed databases. A random effects model was used to estimate the pooled estimates. Results: The meta-analysis has a weighted mean difference of 0.87 g/mL between mild and severe D-dimer (95% CI 0.74, 0.93). There was a significant presence of publication bias. Meta-regression analysis revealed that 58 out of 103 clinical factors correlated with levels of D-dimer. Additionally, age and gender served as confounding variables. Twenty-two variables were discovered to be independently associated with levels of D-dimer, including glucose, respiratory rate, systolic blood pressure, AST, ALT, and bilirubin. Conclusion: In severe cases of COVID-19, elevated D-Dimer levels are associated with the disease. COVID-19 patients may exhibit these laboratory markers, indicating deteriorating health and unfavorable outcomes. | ||
| Keywords | ||
| Keywords: Coronavirus-2; Severe Acute Respiratory Syndrome; D-dimer | ||
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