,, Value soluble CD163/ as a biomarker for diagnosis/ and evaluation of lupus nephritis,, | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 190-201 PDF (1.03 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.362202.1464 | ||
| Authors | ||
| Roba Ayman Khalil* 1; rehab moustapha Golam2; soha hassan sinara3; Yasser Ezzat Taha4 | ||
| 1rheumatology and rehabilitation, faculty of medicine, fayoum university | ||
| 2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum | ||
| 3Rhumatology and Rehabilitaion departement ,Faculty of medicine ,Fayoum Nniversity | ||
| 4Rheumatology and Rehabilitaion department, Faculty of medicine, Fayoum University | ||
| Abstract | ||
| Systemic lupus erythematosus (SLE) is a chronic multisystemic illness that happen in a remitting and relapsing nature. The renal system is among the most important and prevalent affected system in Systemic lupus. Urine Soluble Cluster of Differentiation 163 (us CD163) have been explored as indicators for lupus nephritis (LN) activity in cases with systemic lupus.This research aimed to evaluate UsCD163 levels in systemic lupus cases with or without active lupus nephritis as a potential marker for LN diagnosis and activity assessment. The study enrolled 52 cases (46 Females and 6 males) with 25 gender and age matched controls. UsCD163 was measured in urine sample of patients by (ELISA) technique. The receive operating characteristic curve has been utilized to as discriminatory value of urine soluble CD163 for differentiating cases with active lupus nephritis (ALN) from cases with no kidney activity.There were 6 men and 46 women, with an average age of (33.6±8.8) y. There were 27 active LN and 25 NRA systemic lupus cases. UsCD163levels were high in SLE cases (7±3.6) compared to controls (4.4 ±1.03, p < 0.001). ALN showed considerably greater levels (9.3 ±3.5) compared to NRA SLE patients (4.5 ± 1.3) and controls (p-value < 0.001). The ideal cut-off value for normalized UsCD 163 to anticipate kidney activity was > 4.58, 75% sensitivity, 52% specificity, and p < 0.001. UsCD163 could be a measure of renal illness activity in SLE cases. It distinguishes between cases with ALN and SLE patients with no renal activity. | ||
| Keywords | ||
| Urinary biomarker; systemic lupus erythematosus; M2 macrophages and Renal SLEDAI | ||
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