Potential value of hematological biomarkers in assessment of inflammatory response and disease activity in patients with systemic lupus erythematosus | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 202-2012 PDF (665.6 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.344780.1434 | ||
| Authors | ||
| Maha Nassr* 1; Hanan Mohamed Fathi2; Heba Eid Tolba3; Othman Zaki4 | ||
| 1Assistant professor of Rheumatology, Fayoum Faculty of Medicine | ||
| 2Rheumatology and Rehabilitation Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt | ||
| 3Rheumatology & Rehabilitation department, Fayoum university | ||
| 4Clinical Pathology Department, Damietta University | ||
| Abstract | ||
| Introduction: Remissions and relapses are hallmarks of systemic lupus erythematosus (SLE). The intricacy of SLE persons' clinical presentations causes erroneous assessment of disease progression. As disease activity indicators for SLE, blood indices like the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV). Aim of the study: For the purpose of studying the relevance of NLR, PLR, and MPV to SLE patients' clinical outcomes. Additionally, their correlation with SLE activity. Subjects and Methods: The research included 63 individuals with SLE (58 females and 5 males) as well as 39 age and sex-matched controls. A complete clinical examination, laboratory investigations, and the SLE disease activity index (SLEDAI) were conducted on the patients. The NLR, PLR, and MPV were calculated from the CBC results. Estimation of serum procalcitonin (PCT) level by ELISA. Results: The NLR and PLR values in SLE persons were substantially elevated than controls (2.5 vs. 1.52 and 189 vs. 108.5, respectively; p≤0.0001). PCT levels showed no significant difference (p=0.174). Both NLR and PLR correlated with SLEDAI scores (r=0.852, p<0.0001 and r=0.419, p=0.001, respectively). Individuals with nephritis exhibited significantly higher NLR and PLR (p<0.0001). Conclusions: Both the NLR and the PLR were shown to be much greater in SLE persons than in healthy controls. Potentially helpful biomarkers for evaluating disease activity in SLE and lupus nephritis patients include the NLR and the PLR. | ||
| Keywords | ||
| Keywords: (SLE; disease activity; hematological biomarkers; lupus nephritis) | ||
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