The impact of serum magnesium level and use of proton pump inhibitors on cardiovascular calcification in Participants with chronic kidney disease | ||
| Fayoum University Medical Journal | ||
| Volume 15, Issue 3, September 2025, Pages 238-251 PDF (840.9 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.345170.1432 | ||
| Authors | ||
| Karem M. Salem11; Dina A. Ahmed 2* 2; Mostafa K. Ibrahim3,3; Tarek I. Ahmed11 | ||
| 11 Internal Medicine Department, Faculty of Medicine, Fayoum University, Fayoum 63511, Egypt. | ||
| 22 Nephrology Unit, Om El Masreen General Hospital, Giza, Egypt. | ||
| 33 Cardiology Department, Faculty of Medicine, Fayoum University, Fayoum 63511, Egypt. | ||
| Abstract | ||
| Cardiac disease (C.V.D) continues to be the major cause of mortality for people with chronic kidney disease (C.K.D), which affects around 9.1% of the world's population [1]. Vascular calcification is one of the best indicators of C.V.D, and those with chronic kidney disease (C.K.D) have a much greater disease load and a faster rate of vascular calcification development [2]. Vascular calcification, which mostly affects the medial layer of blood arteries but can also affect the intima, is typified by diffuse mineral deposition in C.K.D Participants. It mostly affects the aorta, although plain X-rays sometimes show a characteristic tramline pattern of calcification that reaches into the tiny capillaries on the periphery. Vascular calcification is more common when renal clearance deteriorates, and it often appears years sooner in renal disease Participants than in controls Numerous severe side effects, such as ischaemic heart disease and an elevated risk of cardiovascular and all-cause death, are linked to vascular calcification. Vascular calcification plays a crucial part in these consequences, but there are presently no targeted treatments to halt its growth or undo its effects. Finding the risk factors causing vascular calcification and creating efficient preventative measures are crucial in light of this treatment gap. By addressing these issues, C.K.D Participants' cardiovascular load may be lessened, improving their prognosis and quality of life in the process | ||
| Keywords | ||
| Chronic kidney disease; Hemodialysis; Hypomagnesemia; Proton pump inhibitors; Vascular calcification | ||
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