MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation
Ramadan, Y., Kamal, A., Medhat, M., Hetta, H. (2025). MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation. EKB Journal Management System, (), -. doi: 10.21608/bfsa.2025.411338.2677
Yasmin N Ramadan; Ayat M Kamal; Mohammed A Medhat; Helal F Hetta. "MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation". EKB Journal Management System, , , 2025, -. doi: 10.21608/bfsa.2025.411338.2677
Ramadan, Y., Kamal, A., Medhat, M., Hetta, H. (2025). 'MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation', EKB Journal Management System, (), pp. -. doi: 10.21608/bfsa.2025.411338.2677
Ramadan, Y., Kamal, A., Medhat, M., Hetta, H. MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation. EKB Journal Management System, 2025; (): -. doi: 10.21608/bfsa.2025.411338.2677

MicroRNA-155 Overexpression in Inflammatory Bowel Disease Patients: Potential Role in Inflammation and Immune Regulation

Bulletin of Pharmaceutical Sciences Assiut University
Articles in Press, Accepted Manuscript, Available Online from 22 September 2025
Document Type: Original Article
DOI: 10.21608/bfsa.2025.411338.2677
Authors
Yasmin N Ramadan* 1; Ayat M Kamal2; Mohammed A Medhat3; Helal F Hetta2
1Department of microbiology and immunology, Faculty of pharmacy, Assiut University
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
3Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University
Abstract
Background:

MicroRNA-155 (miR-155) is a pro-inflammatory molecule implicated in autoimmune and inflammatory diseases, including inflammatory bowel disease (IBD). This study evaluated circulating miR-155 expression in IBD patients versus healthy controls and its association with clinical markers.

Methods:

Thirty IBD patients (20 ulcerative colitis [UC], 10 Crohn’s disease [CD]) and 20 age- and sex-matched healthy controls were enrolled. Plasma miR-155 levels were measured using qRT-PCR. Clinical data included C-reactive protein (CRP), fecal calprotectin, and Mayo score (for UC). Analyses were conducted using SPSS v26.0.

Results:

miR-155 expression was significantly elevated in IBD patients (median fold change: UC = 24.2, CD = 37.5, controls = 1.00; p < 0.0001). No significant difference was observed between UC and CD groups. miR-155 positively correlated with fecal calprotectin (ρ = 0.475, p = 0.008) and Mayo score in UC patients (ρ = 0.748, p < 0.001).

Conclusion:

Circulating miR-155 is significantly overexpressed in IBD and correlates with intestinal inflammation and disease activity, supporting its utility as a non-invasive biomarker.
Keywords
Keywords: inflammatory bowel disease (IBD); MicroRNA-155 (miR-155); fold change; inflammatory markers
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