Role of Berberine Nanoparticles in Treatment of Ulcerative Colitis: A Comprehensive Review | ||
| The Egyptian Journal of Hospital Medicine | ||
| Volume 100, Issue 1, July 2025, Pages 4382-4386 PDF (449.74 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2025.454567 | ||
| Abstract | ||
| Background: Ulcerative colitis, a form of inflammatory bowel disease, involves repeated episodes of inflammation and ulcer formation in the colon. Its development is influenced by a combination of genetic predisposition, age, sex, and environmental conditions. The isoquinoline alkaloid berberine (BBR), which is frequently used as an antidiarrheal, is extracted from the rhizome of the Ranunculaceae plant Coptis chinensis, also known as "Huang-Lian" in Chinese. The use of BBR and its derivatives to treat irritable bowel disease (IBD) has recently been investigated. It is important to remember that BBR may reduce intestinal inflammation in a variety of ways. The effectiveness and bioavailability of BBR are probably going to be enhanced by nanoparticles. Objective: This article aimed to investigate the potential therapeutic benefits of berberine nanoparticles in the management of ulcerative colitis. Methods: We searched PubMed, Google Scholar, and Science Direct for Ulcerative colitis, Berberine nanoparticles, MAPK signaling pathway, Interleukin-6 and Nrf2 signaling pathway. Only the most recent or thorough investigation, from 2013 to 2023 was taken into account. The writers evaluated relevant literature references as well. Documents written in languages other than English have been ignored. Papers that were not regarded as significant scientific research included dissertations, oral presentations, conference abstracts, and unpublished manuscripts were excluded. Conclusion: The observed downregulation of INOS2 and MAPK 14 mRNA expression in colon specimens treated with BBR NP accounted for the anti-inflammatory action of both BBR NP. Additionally, the strong Nrf2/HMOX1 pathway activation of BBR demonstrated its antioxidant impact. | ||
| Keywords | ||
| Ulcerative colitis; Berberine nanoparticles; MAPK signaling pathway; Interleukin-6; Nrf2 signaling pathway | ||
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