Immunohistochemical Assessment of CD1a and Ki-67 in Oral Lichen Planus. | ||
| Egyptian Dental Journal | ||
| Volume 71, Issue 4 - Serial Number 3, October 2025, Pages 3007-3017 PDF (3.67 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2025.344168.3305 | ||
| Authors | ||
| Ibrahim Gamal Elhanafy* 1; Mahmoud Fathy Elsherbeny2; Sherif Yousef Elnagdy3; Nadia A.I. ELSISSY4 | ||
| 1Post Graduate Master Student, Department of Oral Pathology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. | ||
| 2Assistant professor, Department of Oral Pathology, Faculty of Dentistry, Mansoura University and Horus University, Egypt. | ||
| 3Professor of oral pathology, Faculty of Dentistry, Mansoura University and Horus University, Egypt. | ||
| 4Professor of oral pathology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. | ||
| Abstract | ||
| Objective: The purpose of the current study was to assess the expression of CD1a by Langerhans cells (LCs) and cell proliferation by analyzing the expression of Ki-67 in 30 cases of oral lichen planus (OLP). Material and methods: Immunohistochemical staining was used to analyze the expression of CD1a and Ki-67 in 30 archival paraffin blocks containing OLP specimens including 19 erosive, 6 reticular, 3 atrophic, and 2 plaque types of OLP. Normal oral mucosa served as a control. The tissue samples were thoroughly examined, and the expression pattern was analyzed quantitatively by counting the number of positive cells. SPSS-13 program was used for the statistical analysis, and p<0.05. Results: All the studied cases revealed positive reactions to both CD1a and Ki-67. CD1a was weakly expressed in 43.3% of the studied OLPs, distributed within the existing epithelium. Meanwhile, intense expression of CD1a was 26.7% of the studied OLPs, shown among both epithelium and connective tissue stroma, 75% of them were erosive (37.5%) and reticular OLP (37.5%). For Ki-67, the basal and suprabasal epithelial cells as well as the inflammatory cells of 26.7% of the OLPs under study exhibited a low nuclear response. Conclusions: The increase density of Langerhans cells in the studied OLPs suggests its possible significant role in the adaptive immune response in OLP pathogenesis. Elevated ki-67 expression in erosive OLP with severe oral epithelial dysplasia (OED) may indicate that this type is more susceptible to premalignancy and uncontrollable proliferation. | ||
| Keywords | ||
| Oral Lichen Planus (OLP); Oral Epithelil Dysplasia(OED); potentially malignant disorders(PMD) | ||
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