Hyponatremia in Critically Ill Patients and its Relation to the Outcomes | ||
| The Egyptian Journal of Hospital Medicine | ||
| Volume 100, Issue 1, July 2025, Pages 4446-4453 PDF (444.42 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2025.454653 | ||
| Abstract | ||
| Background: Hyponatremia, defined as a serum sodium (Na⁺) concentration below 135 mmol/L, is the most encountered electrolyte abnormality. Objectives: This study aimed to ascertain causes, outcomes (duration and mortality) of hyponatremia and management in critically ill cases in intensive care unit (ICU). Subjects and methods: The current study conducted at Faculty of Medicine, Mansoura University, and was performed on 50 patients with hyponatremia with serum above 18 years old. Laboratory investigations included complete blood count (CBC), Arterial Blood gases, liver functions tests, renal functions tests, serum electrolytes (Na⁺, K⁺, Mg²⁺, Phosphorus and Calcium), coagulation profile, C-reactive protein (CRP), fasting Blood sugar levels, serum uric acid, fasting lipid profile, serum osmolality and urine analysis. Result: The median age was 66 years, indicating a predominantly elderly population. The median SOFA score was 9. Serum osmolality was decreased, indicating true hypotonic hyponatremia. The median Urinary sodium was 27 mmol/L. On univariate analysis, three predictors were statistically significant which are SOFA score > 9, platelet count ≤ 57 per mm3, and AST > 48 IU/L. On multivariate analysis, only one was statistically significant independent predictor which is SOFA score > 9. The model was statistically significant ( c2 [5] = 30.022, p<.001). The model correctly classified 88% of cases, with 87.5% sensitivity, and 88.2% specificity. Conclusion: This study demonstrates that SOFA score is the only independent predictor of ICU mortality, highlighting the importance of overall organ dysfunction over sodium level alone in outcome prediction. | ||
| Keywords | ||
| Hyponatremia; Critically Ill Patients; ICU | ||
|
Statistics Article View: 17 PDF Download: 6 |
||
