Soluble Klotho Levels in Prediction of Premature Vascular Aging in Children with Chronic Kidney Disease | ||
| The Egyptian Journal of Hospital Medicine | ||
| Volume 100, Issue 1, July 2025, Pages 4464-4471 PDF (498.34 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2025.454656 | ||
| Abstract | ||
| Background: In pediatrics, chronic kidney disease (CKD) and its accompanying cardiovascular (CV) adverse events are frequently predominant. The degree of vascular calcification could be utilized as a measure of biologic vascular age, suggesting that cases with kidney disorders could display an accelerated form of vascular ageing. CKD is a pathological condition characterized by Klotho deficiency as it is a primary source of circulating Klotho. Aim: This study aimed to correlate soluble klotho (s-klotho) as a new biochemical marker to premature vascular aging to achieve better outcomes in children with CKD. Methods: This prospective observational study included 90 children and divided into three groups, group 1 included 30 cases of pre-dialysis patients, group 2 included 30 cases of dialysis patients and group 3 included 30 healthy children of matched age and sex. Measurement of serum klotho level was done by ELISA. Ultrasound assessment of intimal thickness in the right and left common carotids was done. Results: The mean SBP, mean DBP and stage of kidney disease were statistically significantly lower in the CKD group compared to the dialysis group. There was insignificant difference between the three groups regarding serum klotho level and carotid intima-media thickness of right common carotid (CC), left CC, minimum diameter and maximum dimeter at baseline and at follow up. Conclusion: There was no correlation between serum klotho level with carotid artery intima media thickness (CIMT) either at baseline or during follow up and no relationship between it and CKD stage. Lack of significant correlation could be due to small included sample size. | ||
| Keywords | ||
| Klotho; Vascular aging; CKD | ||
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