Intrathecal Fentanyl Versus Intravenous Granisetron for the Prevention of Perioperative Nausea and Vomiting During Cesarean Delivery | ||
| Ain-Shams Journal of Anesthesiology | ||
| Volume 17, Issue 1, January 2025, Pages 1-6 PDF (372.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asja.2025.327645.1170 | ||
| Authors | ||
| Bahaa mohammed refaie* ; Mohammed Youssef Mohammed Abdellah; Elhadad Ali Mousa Hammam; hala mohammed Hashem | ||
| Department of Anesthesia and ICU Department, Faculty of Medicine, Sohag University, Egypt. | ||
| Abstract | ||
| Background: About 66% of cesarean sections (CS) done under intrathecal (IT) anesthesia experience intraoperative nausea and vomiting (IONV). This may increase the aspiration risk, induce discomfort for the patient, and complicate the surgery. Numerous strategies have been employed to diminish the occurrence of perioperative nausea and vomiting; however, they contribute to increased costs and adverse effects. Objective: To assess the efficacy of IV Granisetron compared to IT fentanyl in reducing Perioperative nausea and vomiting during CS performed under IT anesthesia. Methods: Ninety patients, aged 18 to 45, with ASA grade I or II scores, were included in the study for CS under spinal anesthesia. 3 groups were involved in the study: the IV Granisetron (1 mg) group, the IT fentanyl (20 µg) group, and a control group. The frequency of nausea and vomiting was evaluated intraoperatively using the nausea and vomiting evaluation score. Postoperative pain was evaluated using the VAS, and unpleasant symptoms such as headache and pruritus were also noted. Results: Patients in groups F and G exhibited significantly reduced IONV compared to group C (P value <0.05). Moreover, group F had significantly fewer patients (P value<0.001) than groups G and C, who got analgesics within one-hour post-surgery, and no severe side effects were seen. Conclusion: In CS performed under IT anesthesia, fentanyl (20 micrograms) may be more efficacious in mitigating IONV compared to IV Granisetron (1 mg). | ||
| Keywords | ||
| Caesarean delivery; fentanyl; Granisetron; Nausea and vomiting | ||
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