Effect of Two Different Doses of Oral Pregabalin Premedication for Postoperative Pain Relief after Gynecological Surgeries: A Randomized Controlled Study | ||
| Ain-Shams Journal of Anesthesiology | ||
| Volume 17, Issue 1, January 2025, Pages 1-10 PDF (440.98 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asja.2025.337921.1183 | ||
| Authors | ||
| Asmaa M. Galal Eldin* ; Ahmed M. Awadalla; Rehab A. Wahdan | ||
| Department of Anesthesia, Intensive Care, and Pain Management. Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| Background: The introduction of minimally invasive surgical techniques is associated with earlier postoperative ambulation, but controlling the postoperative pain didn’t achieve the level of full control. Pregabalin has been shown to have perioperative analgesic effects. Aim of the work: Assessment and comparison between the effects of two different doses of oral pregabalin premedication in gynecological surgeries under spinal anesthesia regarding postoperative analgesia and side effects. Patients and methods: Ninety female patients scheduled for gynecological operations were randomized to receive the study drug one hour before the operation according to each group; one placebo capsule of vitamin C (group C), one capsule of pregabalin 150 mg once (group P1) or one capsule of pregabalin 300 mg once (group P2). The primary outcome was the analgesic effects of pregabalin using visual analogue scale (VAS). Results: The VAS score was statistically significantly lower in group P1 and group P2 compared to group C at 4, 6 and 8 hours postoperative (p 0.001). The time to first analgesic recall was statistically significantly prolonged in both group P1 and group P2 as compared to group C (P < 0.001), furthermore, it was statistically significantly prolonged in group P2 compared to group P1. Conclusion: The current study reveals the analgesic efficacy of pregabalin when administered as a premedication in patients undergoing gynecological surgeries under spinal anesthesia with lower post-operative VAS scores, lower doses of rescue analgesics needed and Pregabalin 300 mg had a better analgesic profile noticed by hastening the onset of sensory and motor block. | ||
| Keywords | ||
| Gynecological; Pregabalin; Spinal; Visual analogue scale | ||
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