Efficacy of Aleo Vera in Prevention and Treatment of Chemotherapy-induced Oral Mucositis in A group of Egyptian Children with Acute Leukemia: Randomized Controlled Trial. | ||
| Ain Shams Dental Journal | ||
| Volume 38, Issue 2, June 2025, Pages 143-152 PDF (1.2 M) | ||
| Document Type: Consort randomized clinical trials (RCT) | ||
| DOI: 10.21608/asdj.2025.374881.1969 | ||
| Authors | ||
| Sarah Nabil* 1; Reham khaled Elghazawy2; Nagwa Mohammed Ali Khattab3 | ||
| 137FV+PH3، شارع منظمة الوحدة الافريقية، كوبري القبة، الوايلى، محافظة القاهرة 4393005 | ||
| 2Pediatric dentistry and dental public health, Faculty of dentistry, Ain shams university | ||
| 3Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Aim: The aim of the study was to evaluate the efficacy of Aloe Vera (AV) in prevention and treatment of chemotherapy-induced oral mucositis(CIOM) in a group of Egyptian children suffering from acute leukemia in terms of appearance and severity. Materials and Methods: A randomized controlled trial (RCT) was conducted over a period of 2 months at Nasser Institute Hospital for Research and Treatment (NIH). The study included 40 patients undergoing treatment for acute lymphoblastic leukemia (ALL). They were assigned into two groups; in the intervention group (20 patients) applied 70% AV gel topically three times daily, starting three days before chemotherapy and over a period of two months. While, the control group did not receive this treatment; instead, they used routine mouthwashes prescribed by their physicians, including chlorhexidine or nystatin. Results: At baseline, all the cases in both groups were free from oral mucositis (OM) .After 2 months, a significantly higher percentage of cases in the control group (85%) were affected in comparison to the study group (15%) (p<0.001). For the study group, the mean onset was 19 days , while for the control group, the mean was 13 days. All cases with OM in study group presented with lower grades of severity than the control group. Conclusion: AV had a significant effect in preventing CIOM and notably reduces both the duration and severity of symptoms compared to the control group. These findings suggest that AV gel could be a valuable therapeutic option for managing CIOM. | ||
| Keywords | ||
| Aloe Vera; Oral Mucositis; Acute Lymphoblastic Leukemia; Acute leukemia | ||
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