KIDNEY INJURY MOLECULE-1 AND FRACTIONAL EXCRETION OF UREA IN ACUTE RENAL IMPAIRMENT IN HCV DECOMPENSATED CIRRHOSIS | ||
ALEXMED ePosters | ||
Volume 7, Issue 3, July 2025, Pages 63-64 | ||
Document Type: Preliminary preprint short reports of original research | ||
DOI: 10.21608/alexpo.2025.427058.2275 | ||
Authors | ||
Nasser Mohamed Abdullah1; Doaa Ahmed Elwazzan2; Rasha Said Omar3; Osama Taha Mohamed Elsaber* 1 | ||
1Department of Tropical Medicine, Faculty of Medicine, Alexandria University | ||
2Tropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||
3Department of Medical Biochemistry, Faculty of Medicine, Alexandria University | ||
Abstract | ||
Acute kidney injury (AKI) is a frequent and serious complication in cirrhosis, particularly in Egypt where HCV is a leading cause. Conventional markers like creatinine are unreliable in cirrhotic patientsdue to altered hepatic metabolism, muscle wasting, and the use of diuretics. This has highlighted the need for novel biomarkers that improve diagnostic accuracy and allow earlier detection of renal injury. Urinary kidney injury molecule-1 (KIM-1) and the fractional excretion of urea (FEUrea) have emerged as promising tools, but their performance in HCV-related cirrhosis remains underexplored. Aim: This study aimed to evaluate the diagnostic performance of urinary KIM-1 and FEUrea in detecting and characterizing AKI in patients with HCV-related cirrhosis, and to assess their relationship with liver disease severity scores. Patients and Methods Eighty-five participants were studied: 35 cirrhotics with AKI, 35 without AKI, and 15 controls. Urinary KIM-1 was measured by ELISA, and FEUrea calculated from urine/serum urea. Liver disease severity was assessed by Child-Pugh, MELD, and MELD-Na scores. Biomarker levels were compared across groups, with ROC analysis for diagnostic accuracy and evaluation of AKI subtypes. | ||
Keywords | ||
Hepatitis C Virus (HCV); Decompensated Cirrhosis; Acute Kidney Injury (AKI); Kidney Injury Molecule-1 (KIM-1); Fractional Excretion Of Urea (Feurea) | ||
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