Relationship Between Biomarker of Human Calprotectin with Rheumatoid Arthritis | ||
| Journal of Bioscience and Applied Research | ||
| Article 12, Volume 11, Issue 3, September 2025, Pages 860-870 PDF (677.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.455219 | ||
| Authors | ||
| Hussein Mahdi Kadhim1; Arshad Noori AL-DUJAILI* 2 | ||
| 1University of Karbala College of Medicine / Iraq | ||
| 2Biology Department, College of Science -University of Kufa, Iraq | ||
| Abstract | ||
| The etiology of RA, a chronic inflammatory joint disease, is complex and involves the immune system. One of the main components of neutrophils and polymorphonuclear granulocytes, which have been linked to the pathophysiology of autoimmune inflammatory illnesses like RA, is calprotectin. Comparing the human calprotectin biomarker in rheumatoid arthritis patients to that of the healthy group was the goal of the study. Female patients in this study were collected from rheumatoid arthritis clinics in Karbala city. Blood samples were taken from about 50 healthy women in the control group and 80 patients who had RF disease. The information regarding patients and samples was collected, and statistical analyses were carried out between the control samples and human calprotectin levels in Rheumatoid arthritis patients, showing a highly substantial rise in CLP levels (P < 0.001). When comparing women with rheumatoid arthritis to those in the control group, there was also a significant rise (p < 0.001) in the CLP level by age and before or after menopause. According to statistical analysis, the new diagnostic group's serum human CLP level (102.76 ±0.72 ng/ml) was substantially greater (p < 0.001) than the treated group's. Furthermore, compared to the overweight and normal weight groups, the obese group's blood level of human CLP was considerably (p<0.001) greater. Furthermore. According to our findings, serum human CLP in women having RA had a negative correlation with estradiol-17b and a positive correlation with RF and ACPAs. | ||
| Keywords | ||
| RA; calprotectin; autoimmune inflammatory illnesses | ||
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