Differentiation between Primary fibromyalgia and Middle East Pain syndrome regarding Serum IL-6 level and MRI changes in hands and knees joints | ||
Al-Azhar International Medical Journal | ||
Volume 2025, Issue 5, May 2025, Pages 73-77 PDF (346.57 K) | ||
Document Type: Original Article | ||
DOI: https://doi.org/10.21608/aimj.2025.446556 | ||
Authors | ||
Sahar Salah Ismail* 1; Adel Abbas Elbeialy1; Sabah Ibrahim Abdelraheem2; Maha Salah Eldin Mohamed1 | ||
1Department of Rheumatology and Rehabilitation, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
2Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. | ||
Abstract | ||
Background: Fibromyalgia syndrome(FMS) is defined by the dysregulation of neuroendocrine function and/or nociceptive processing. Middle East Pain Syndrome(MEPS) is characterized by fibromyalgia that is accompanied by 2ry hyperparathyroidism and deficiency of vitamin D3. Aim: To differentiate between primary fibromyalgia and MEPS in terms of serum IL-6 level and MRI changes in the joints of the hands and knees. Patients and methods: This investigation involved forty cases diagnosed as MEPS and 40 patients with primary fibromyalgia. Full history taking, clinical examination, laboratory investigations involving vitamin D3, parathyroid hormone(PTH) and IL-6 serum levels, and MRI of both hand and knee joints. Results: Vitamin D3 levels decreased in both groups, with a significant reduction in the MEPS group in comparison with the FMS group. IL-6 levels increased in both groups without significant differences, but correlated with clinical severity scores. PTH levels were significantly greater in the MEPS group (p-value less than 0.001). Hand MRI showed more spur excrescences and degenerative changes in the MEPS group(p-value less than 0.05). Knee MRI revealed higher chondrocalcinosis in the MEPS group, increasing with age and disease duration, while synovial hypertrophy showed no significant difference. Conclusion: Vitamin D3 serum level decreased in both MEPS and FMS cases, significantly decreasing in the MEPS group compared to the FMS group, necessitating assessment and correction. IL-6 serum level increased in both groups with an insignificant difference; it positively correlates with clinical manifestations. MRI showed increased chondrocalcinosis and degenerative changes in MEPS patients. | ||
Keywords | ||
Primary fibromyalgia; Middle East Pain syndrome; Serum IL-6 level; MRI changes | ||
Statistics Article View: 5 PDF Download: 3 |