Effectiveness of Platelet-Rich Plasma Nasal Packing in Endoscopic Sinus Surgery: A Randomized controlled trial | ||
| ARCADEs of MEDICINE | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 September 2025 | ||
| Document Type: Original Research | ||
| DOI: 10.21608/arcmed.2025.420952.1168 | ||
| Authors | ||
| Ahmed yassin Gohar* 1; Soaad Yehia Mostafa2; Wesam Roshdy Mohammed3; Ahmed Yehia Abou Elenein4; walid abdel fattah sorour3; Rania rady kadis5; Tahany Mohamed Rabie6 | ||
| 1Otorhinolaryngology Department, Armed Forces college of medicine, Cairo, Egypt | ||
| 2Otorhinolaryngology Department, Armed Forces College of Medicine, Cairo, Egypt | ||
| 3Otorhinolaryngology Department, Military medical academy, Cairo, Egypt | ||
| 4otorhinolaryngology, Armed Forces College of Medicine, Cairo, Egypt. | ||
| 5Clinical pathology Department , Armed Forces Medical Complex, Alexandria, Egypt. | ||
| 6Otorhinolaryngology Department, Ain Shams University,Cairo, Egypt | ||
| Abstract | ||
| Chronic rhinosinusitis (CRS) is a significant condition impacting millions globally. It is marked by chronic inflammation of the mucosal lining and sinuses. The objective of this study was to assess the impact of platelet-rich plasma packing on mucosal healing and tissue regeneration rates following endoscopic sinus surgery. Methods: This study was an open-label randomized controlled trial conducted at the ENT Department of Alexandria Military Medical Complex, Kobry El Kobba Military Medical Complex, and the ENT Audiology and Phoniatric Hospital at Galaa Military Medical Complex, involving 34 patients with chronic rhinosinusitis scheduled for endoscopic sinus surgery (ESS). Results: The Lund-Mackay CT scores demonstrated no significant disparities across groups preoperatively, indicating equivalent baseline sinus involvement. The SNOT-22 scores for the PRP and control groups commenced at similar moderate symptom levels. The preoperative total Lund-Kennedy scores for both groups were similar (PRP: 7.47 ± 0.51 vs. Control: 7.35 ± 0.49, p = 0.501). The SNOT-22 scores exhibited significant disparities between the PRP and control groups. The PRP group had consistently greater improvement. Within three months, all PRP patients achieved minimum symptom status, in sharp contrast to the control group, which remained in the mild symptom category. The Lund-Kennedy and the Visual Analog Scale (VAS) scores were measured. Conclusion: Platelet-rich plasma nasal packing shows considerable promise in enhancing surgical results for individuals with chronic rhinosinusitis, including improved symptom resolution, diminished pain, and decreased recurrence rates relative to conventional surgical methods. | ||
| Keywords | ||
| Endoscopic Sinus Surgery; Platelet-Rich Plasma; Nasal Packing; Randomized controlled trial | ||
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