Importance of Urinary Monocytic Chemoattractant Protein-1 as a Non Invasive Biomaker for lupus Nephritis Activity | ||
| Al-Azhar International Medical Journal | ||
| Volume 2025, Issue 5, May 2025, Pages 107-113 PDF (431.35 K) | ||
| Document Type: Original Article | ||
| DOI: https://doi.org/10.21608/aimj.2025.446562 | ||
| Authors | ||
| Safwat Farrag Ahmed1; Alsayed Mohamed Rashed2; Mohamed Elsayed Abo Ghabsha3; Abdelaziz Refaat Abdelaziz* 4 | ||
| 1Professor of Internal Medicine and Nephrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2Assistant Professor of Internal Medicine and Nephrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 3Assistant Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 4MSc, Internal Medicine and Nephrology , Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: About 40-60% of people with systemic lupus erythematosus (SLE) will also have lupus nephritis (LN), a renal involvement symptom that can show in a variety of ways. Aim and objectives: For the purpose of assessing uMCP-1, or urine monocyte chemotactic protein-1, as a noninvasive indicator of lupus nephritis activity Subjects and methods: Of the 90 participants in this cross-sectional study, 30 were healthy controls of the same age and sex, and 60 were patients with SLE according to four or more American College of Rheumatology criteria. The participants' ages ranged from 18 to 55. From May 2023 through January 2024, patients were enrolled from the nephrology outpatient clinics and inpatient wards of Al-Azhar University Hospitals. Results: The active LN group had significantly greater urinary MCP-1 levels compared to the inactive LN group and controls (p~0.001). A strong positive connection was found between uMCP-1 and LN activity. Highly significant (p<0.001). In the active LN group, uMPC-1 was positively correlated with 24-hour urine protein, anti-dsDNA, renal SLEDAI, and biopsy activity index. Conclusion: There is a strong association between the clinical and laboratory parameters of the activity investigated and the urinary MCP-1 levels, which reveal a large increase in cases of LN activity. uMCP-1 could differentiate between renal disease that was inactive and active LN and/or recurrence. It reliably detected LN activity and relapse with high sensitivity and specificity, making it an excellent diagnostic tool. | ||
| Keywords | ||
| Lupus nephritis activity; uMCP-1 | ||
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