Hyaluronic Acid Versus Botulinum Toxin Type A Injection in the Treatment of Premature Ejaculation: Comparative Study | ||
| Al-Azhar International Medical Journal | ||
| Volume 2025, Issue 5, May 2025, Pages 170-174 PDF (371.08 K) | ||
| Document Type: Original Article | ||
| DOI: https://doi.org/10.21608/aimj.2025.446573 | ||
| Authors | ||
| Abd Raouf Mohamed Almohsen Mohamed1; Mohamed Saeed Mohamed Hasan2; Maged Taha Mahmoud Abd Elsalam* 3 | ||
| 1Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2Assistant Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 3MSc, Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: Premature ejaculation (PE) is the most prevalent type of male sexual dysfunction. Possible causes of premature ejaculation include abnormalities in nerve conduction, higher penile sensitivity, hereditary susceptibility, and serotonin receptors. Aim and objectives: To evaluate the efficacy and safety of hyaluronic acid injection and botulinum-A toxin injection in the treatment of premature ejaculation. Subjects and methods: This randomized clinical study included 60-patients collected from outpatient clinics for andrology at Al-Azhar University Hospitals. The patients were divided into two equal groups: (A) and (B) each involving 30-male patients with premature ejaculation. Group-A was given botulinum A and Group-B was given hyaluronic acid. Results: Statistically significant difference regarding control of ejaculation and patient satisfaction in patients injected with BTX. On the other hand, all the results of PEP were statistically significant in patients injected with HA. The mean IELT post-injection was 5.58 minutes, with a mean among patients who received BTX of 3.87 minutes and among those who received HA of 7.3 minutes. This difference is statistically significant. No side effects were reported other than pain in 80% cases of HA injection and 20% of cases of BTX injection. Conclusion: Botulinum toxin A and hyaluronic acid have been shown to be effective in managing premature ejaculation. However, hyaluronic acid has a higher effectiveness than botulinum toxin A in treating premature ejaculation. | ||
| Keywords | ||
| Botulinum toxin A; Hyaluronic acid; Premature ejaculation | ||
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