Therapeutic and Metabolic role of VIT D in psoriasis and psoriatic arthritis | ||
| Sohag Medical Journal | ||
| Volume 29, Issue 3., 2025, Pages 18-24 PDF (1.19 M) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/smj.2025.397400.1583 | ||
| Authors | ||
| Alia Khairy Mahmoud* 1; Soheir Maher Ahmed2; Seham Abd alrahman Abd allatif3; Lamiaa Ahmed Abdel Rahim Abdel Rahman4; Sara Hassan5; Shams mohamed adel Abd El Ale6 | ||
| 1Department of Medical Biochemistry , Faculty of Medicine , Sohag university , Sohag , Egypt | ||
| 2Deparment of Physical Medicine Rheumatology and Rehabilitation | ||
| 3Physiology ,Faculty of medicine, Sohag University | ||
| 4Community medicine, faculty of medicine, Sohag university, Sohag, Egypt | ||
| 5Department of Dermatology, Faculty of medicine, Sohag University, Sohag, Egypt | ||
| 6forensic medicine and clinical toxicology department, faculty of medicine, sohag university | ||
| Abstract | ||
| Psoriasis is a chronic inflammatory skin condition marked by scaly, hardened red plaques, which extend beyond the skin to affect joints and nails. It is often associated with systemic, psychiatric, and psychosocial disorders. Keratinocytes are fundamental in both initiating and maintaining psoriasis as part of the body's innate immune response. These skin cells can react to various environmental stimuli. When stressed, keratinocytes release self-nucleotides and antimicrobial peptides, which in turn activate plasmacytoid dendritic cells (pDCs). This leads to the activation and maturation of myeloid dendritic cells (mDCs), which produce pro-inflammatory cytokines such as IFN-α, IFN-γ, TNF-α, and IL-1β Vitamin D helps maintain the health of the skeletal system and epidermis, regulating keratinocyte differentiation and proliferation. There is a strong connection between vitamin D and the IL-33/ST2 axis in regulating skin and bone homeostasis. This review explores the bidirectional interactions between vitamin D and psoriasis, suggesting a mechanistic link with IL-33 in patients suffering from psoriasis and related osteoporosis (OP). | ||
| Keywords | ||
| Vitamin D, Psoriasis; Psoriatic arthritis, keratinocytes | ||
|
Supplementary Files
|
||
|
Statistics Article View: 44 PDF Download: 34 |
||
