Effects of Bee Venom on Biochemical and Histopathological Alterations in Rat Testicular Tissue Following Busulfan Exposure | ||
| New Valley University Journal of Basic and Applied Sciences | ||
| Articles in Press, Accepted Manuscript, Available Online from 29 September 2025 | ||
| Document Type: Original papers | ||
| DOI: 10.21608/nujbas.2025.374762.1036 | ||
| Authors | ||
| Basant A. Eid1; Elham A Abd-Allah* 1; Hassan A. Hussein2; Regab H. Moneeb1 | ||
| 1Zoology Department, Faculty of Science, New Valley University, 72511 New Valley, Egypt. | ||
| 2Department of Theriogenology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Abstract Background: Busulfan is a frequently administered chemotherapy medication for cancer treatment, but one of its most frequent side effects in male patients is temporary or permanent infertility. Interestingly, animal-derived toxins have demonstrated potential as therapeutic agents for the prevention and management of various health disorders. Aim: This study aimed to evaluate how bee venom (V) affects the biochemical and tissue structure of the testes after Busulfan (B) administration. Methods: semen analysis, biochemical and histological studies were conducted on five groups of control, DMSO, B, V, and BV. Results: Epididymal sperm counts were significantly lowered in the B group in contrast to the control group, with a significant increase in the V group. Dead sperm was significantly increased in the B group, while the V group had a significant decline. Alive sperm showed a significant decrease in the B group with notable elevation in the group that received V treatment. Total protein (TP) and total antioxidant capacity (TAC) were considerably decreased in the B group with a notable increase in the V group, Nitric acid (NO) did the opposite. In addition, the treated V group showed considerable improvement in histoarchitecture compared to the B rats. Conclusion: Bee venom exhibits promising effects in mitigating busulfan-induced testicular injury in rats, primarily through its antioxidant, anti-inflammatory, and pro-survival mechanisms. Keywords: Busulfan, Bee venom, chemotherapy, viability, antioxidant properties. | ||
| Keywords | ||
| Keywords: Busulfan; Bee venom; chemotherapy; viability; antioxidant properties | ||
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