Using Bacillus amyloliquefaciens MSRY J and Trichoderma longibrachiatum MSRY T to Ameliorate The negative Impacts of Aflatoxin B1 in Broilers | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 29 September 2025 PDF (1.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.399145.2935 | ||
| Authors | ||
| Mohamed Elmasry1; Asmaa Shawat2; Mostafa Shalaby2; Nagwa El-Khateeb2; Sahar El-Nagar3; Moustafa Shukry4; Reda Abdallah5; Ola Habotta6; Mahmoud S. Gewaily* 7 | ||
| 1Department of Poultry Nutrition, Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Animal Production Research Station, Sakha, Kafrelsheikh 33511, Egypt | ||
| 2Agricultural Botany Department (Agricultural Microbiology), Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516, Kafrelsheikh, Egypt | ||
| 3Department of Animal Wealth Development, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt | ||
| 4Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt | ||
| 5Food Control Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt | ||
| 6Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt | ||
| 7Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelskeikh University | ||
| Abstract | ||
| This study sought to determine if 2 variable biological additives might reduce the negative effects of aflatoxin B1 (AFB1) on growth performance, gene expression, and histopathological analysis in broilers. A total of 120 male broilers one day old divided into 4 equal groups as follows: Negative control (NC), Positive control (PC) contaminated with 1.0 mg aflatoxin B1 (AFB1)/kg feed, PC with 0.5% Bacillus amyloliquefaciens MSRY J as 1× 108 CFU / kg, and PC with 0.5% wheat bran fermented by Trichoderma longibrachiatum MSRY T. The results showed that the feed conversion ratio recorded a significant improvement in the NC group, followed by T. longibrachiatum MSRY T group compared with groups. The hazard impact of AFB1was revealed on the downregulation of important growth and immune-related genes, however, treatment with T. longibrachiatum MSRY T and B. amyloliquefaciens MSRY J seems to counteract this effect by upregulating the expression of the same genes. Other enhancement effects were recorded for meat quality (pH, cook loss, drip loss and colour parameters). Moreover, the histopathological examination displayed a mitigating effect of the used strains against AFB1 on the liver, kidney, and duodenum. These findings suggest that these biological treatments not only help in manipulating during the contamination period but also aid in recovery and efficient feed utilization afterward. Finally, it could be used as a dietary strategy to ameliorate the negative impacts of AFB1 and counteract mycotoxin-induced molecular disruptions in poultry. | ||
| Keywords | ||
| Aflatoxin B1; Bacillus amyloliquefaciens; Trichoderma longibrachiatum; Broilers | ||
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