Exploring the microstructure, antibacterial, and antioxidant features of Boswellia serrate extract -loaded Alginate/Gelatin porous Scaffolds for medical application | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 4, December 2025, Pages 32-37 PDF (1.34 M) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjcc.2025.420888.1027 | ||
| Authors | ||
| Norhan Atef Attiya* 1; Zakaria Mohamed Allhayat2; Omali Youssef Elkhawaga3; Emad Tolba4 | ||
| 1Biochemistry faculty of science mansoura university | ||
| 2Prof of biochemistry at national research center | ||
| 3Professor of Biochemistry, Chemistry Department, Faculty of Science, Mansoura University | ||
| 4Polymers and Pigments Department National Research center | ||
| Abstract | ||
| This study developed a novel sponge-like hydrogel composed of sodium alginate and gelatin (ALG/GEL) for the incorporation of Boswellia serrata extract (BSE), a promising bioactive agent for tissue regeneration. The synthesized BSE-loaded ALG/GEL scaffolds using emulsion freeze drying method. The obtained emulsion samples were characterized by TEM and DLS. The BSE nanoparticles exhibited an average diameter ranging from 196 ± 52 nm to 368 ± 142 nm, dependent on the BSE content. The bioactivity of the scaffolds was confirmed through a DPPH radical scavenging assay. The pure BSE extract demonstrated significant dose-dependent antioxidant activity with an IC₅₀ value of 72 μg/mL, confirming its inherent potency, though it was lower than the ascorbic acid positive control (IC₅₀ = 17.9 μg/mL). Crucially, the BSE-loaded scaffolds retained this beneficial property in a loading-dependent manner. The 20%BSE-loaded scaffold (IC₅₀ ≈ 78 μg/mL) was significantly more potent than the 10% loaded variant (IC₅₀ ≈ 135 μg/mL), highlighting the efficacy of the loading process. the in vitro findings lead to the conclusion that the developed BSE-loaded ALG/GEL scaffolds are effective antimicrobial agents. These multifunctional properties make the developed scaffold a highly promising candidate for advanced tissue regeneration applications. | ||
| Keywords | ||
| Hydrogel sponges; Boswellia oleo-gum resin; single patch dressing; wound healing | ||
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