Secondary metabolites of four wild medicinal Egyptian plants | ||
| Mansoura Journal of Biology | ||
| Volume 72, Issue 3, September 2025, Pages 8-11 PDF (784.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2025.455948 | ||
| Authors | ||
| Wisam Elshamery1; Ghada A. El-Sherbeny1; Mohamed Abdelaal* 2 | ||
| 1Botany Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt | ||
| 2Botany Department, Faculty of Science, Mansoura University | ||
| Abstract | ||
| This study presents a comparative analysis of the phytochemical constituents and associated bioactivities of four medicinal plants: Aerva javanica (Burm.f.) Juss. ex Schult., Deverra tortuosa (Desf.) DC., Trichodesma africanum(L.) Sm., and Erodium gruinum (L.) L’Hér. Quantitative profiling of secondary metabolites revealed that A. javanica exhibited the highest levels of total phenols (210.40 mg GAE/g) and flavonoids (75.19 mg CE/g), followed by D. tortuosa. Conversely, E. gruinum showed the highest tannin content (10.50 mg TAE/g), suggesting potential astringent and antioxidant roles. Antioxidant capacity, assessed by DPPH (IC₅₀) and ABTS assays, indicated superior radical scavenging in A. javanica (IC₅₀ = 0.129 mg/ml, ABTS = 76.8%), outperforming the standard ascorbic acid (IC₅₀ = 0.022 mg/ml). Antibacterial activity, evaluated by inhibition zone diameters, revealed that D. tortuosa was most effective against S. aureus and A. javanica against E. coli. In vitro anticancer screening against HepG2, MCF-7, and PC3 cell lines showed that A. javanica had the lowest IC₅₀ values (45.6, 50.2, and 48.94 µg/ml, respectively), highlighting its potential as a multi-target anticancer agent. The variations in bioactivity correlated significantly with concentration of bioactive constituents. These findings underscore the therapeutic potential of these desert plants and advocate for their further exploration in drug discovery and natural product research. | ||
| Keywords | ||
| Xerophytes; total phenols; solvent; anticancer; antioxidant | ||
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