The Renin Inhibitor Aliskiren mitigates Diabetes mellitus induced Vascular Impairment of rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Volume 45, Issue 4, October 2025, Pages 519-531 PDF (521.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2025.380783.1213 | ||
| Authors | ||
| Reem M Emam1; Suzan A Khodir* 1; Ahmed Mohamed Gaafar1; Noha Abd El-aziz2; Noha R Noufal3; Nahla M Radwan4; Mohamed Awad Shahien5; Mai A Nasser6; Heba Abdelrazak Abdelfatah7; Esraa A Elnahrawy8 | ||
| 1Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 2Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 3Pathology Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 4Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 5Clinical Pharmacology Department, Faculty of medicine, Damitta University, Egypt | ||
| 6Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 7Histology Department, Faculty of Medicine, Helwan University Egypt. | ||
| 8Physiology Department, Badr University in Cairo (BUC), Cairo, Egypt | ||
| Abstract | ||
| Background: The most prevalent kind of diabetes is type 2 diabetes mellitus (T2DM). Vascular impairment is one of the numerous problems that frequently accompany diabetes mellitus. Renin inhibitors like Aliskiren have been shown to effectively protect organs through a variety of methods. Objective: to illustrate aliskiren's vascular-protective effects in diabetic rats and any possible underlying processes at play. Material and methods: Thirty male albino rats were split into three groups: diabetic, diabetic+aliskiren, and control (10/group). Serum glucose, insulin, HOMA-IR index, glycosylated Hb A1c, cholesterol, triglycerides, renin activity, aortic MDA, aortic SOD, aortic TNF-α, aortic IL-6, aortic IL-10, aortic NF-kB gene expression, and aortic ENOS gene expression were all evaluated. Additionally, aortic histology and immunohistochemical analyses were performed. Results: In contrast to the control group, the diabetic group's aortic SOD, aortic IL-10, and aortic gene expression of ENOS were significantly lower, while the measured serum glucose, insulin, HOMA-IR index, serum glycosylated Hb A1c, serum cholesterol, serum triglyceride, serum renin activity, aortic MDA, aortic TNF-α, aortic IL-6, and aortic gene expression of NF-kB were all significantly higher in the diabetic group. Additionally, as compared to the control group, the diabetic group's aortic ENOS was significantly downregulated and their aortic NF-kB immunoreaction was elevated. Aliskiren considerably reduced the vascular alterations brought on by diabetes. Conclusion: By blocking renin activity and exhibiting hypoglycemic, lipid-lowering, anti-inflammatory, and antioxidant effects in addition to upregulating aortic ENOS, aliskiren guards against diabetes-induced vascular damage. | ||
| Keywords | ||
| Aliskiren; Diabetis Mellitus; ENOS; NF-kB; Renin | ||
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