Isolation, Characterization, and Antibiotic Sensitivity Pattern of Gram-Negative Bacteria Causing Chronic Bacterial Prostatitis. | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Volume 17, Issue 2, December 2025, Pages 189-201 PDF (902.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2025.456223 | ||
| Authors | ||
| Magda M. Mehanni1; Osama M. Sayed2; Ahmed O. El-Gendy3; Walaa G. Hozayen4; Sahar I. Mohammad5 | ||
| 1Department of Botany and Microbiology, Faculty of Science, Minia University, Minia 61519, Egypt. | ||
| 2Departmentof Pharmaceutics, faculty of Pharmacy, Sinai University, Kantara Branch, Ismailia 41612, Egypt. | ||
| 3Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt. | ||
| 4Department of Biochemistry, Faculty of science, Beni-Suef University, Beni-Suef 62511, Egypt. | ||
| 5Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Science, Beni-Suef University, Beni-Suef 62511, Egypt. | ||
| Abstract | ||
| Bacterial prostatitis (BP) is an infection of the prostate gland, it can be acute (ABP) or chronic (CBP). CBP badly affects patient’s life quality, and it can cause significant morbidity if not properly treated. In this study, expressed prostate secretion from 10 patients that are diagnosed with chronic bacterial prostatitis at Kasr Al-Ainy hospital, Egypt is used to isolate the common causative bacteria for CBP. Results indicated that Gram negative bacteria were predominant since 54 Gram-ve bacterial isolates were obtained out of the total 62 isolates. Gram-ve bacterial isolates were grouped according to their oxidase test results and to lactose fermentation capability into three groups. The largest group contained 38 isolates of oxidase negative, lactose fermenters and related to Enterobacter cloacae complex. The oxidase positive lactose non-fermentors group contained 9 isolates while the oxidase negative lactose non-fermentors group contained 7 isolates. They were identified by 16S rRNA sequence homology to be a strain of Pseudomonas stutzeri and Providencia stuartii respectively. Antibiotic sensitivity pattern of chosen representative isolates indicated that all of them were sensitive to ciprofloxacin followed by ampicillin while resistance to cefaclor and aztereonam was prevalent. Other tested antibiotics recorded different sensitivity patterns. Enterobacter cloacae was the most prevalent. This study targeted mainly the isolation of the prevalent bacterial pathogens causing chronic bacterial prostatitis in Egypt and to determine their antibiotic resistance pattern for better future treatment. | ||
| Keywords | ||
| Chronic Bacterial Prostatitis; Ciprofloxacin; Enterobacter cloacae; Enterobacter kobei; Pseudomonas stutzeri; Providencia stuartii | ||
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