The possible ameliorating effect of date (Phoenix Dactelifera L) against brain toxicity induced by AlCl3 in male rats | ||
| Mansoura Journal of Biology | ||
| Volume 58, Issue 5, December 2022, Pages 11-25 PDF (856.97 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456323 | ||
| Authors | ||
| Nadia Salh; Mamdouh El-Sawi; Hanaa Serag* | ||
| Zoology Department-Faculty of Science-Mansoura university | ||
| Abstract | ||
| The study aims to see if date palm fruits (Phoenix Dactelifera L) could protect male albino rats from neurological abnormalities and oxidative stress caused by ALCL3 exposure. In rats given AlCl3 at a dose of 100 mg/kg, levels of brain neurotransmitters, DA , 5-HT, AChE, Na-K ATPase activity, and ATP value are significantly decline, whereas the level of NE was elevated. Furthermore, AlCl3 intoxicated rats had a large rise in the end product of the brain lipid peroxidation, MDA and in NO, H2O2 levels, and the activity of xanthine oxidase (XO), as well as a pronounced drop in the antioxidant parameters, TAC, SOD, and GSH. As well as the apoptotic marker, Caspas3, Caspase9, Bax, and Bax/Bcl 2 showed a significant increase, while a decrease in anti-apoptotic marker ,Bcl2 was recorded. As well as, the serum levels of Na, and Ca were significantly decreased, while the level of K was elevated. Serum TC, TG, LDLC, and VLDL levels, as well as the TC/HDL and LDL/HDL ratios, all increased significantly, while serum HDLC levels declined dramatically. Supplementation with date palm fruit (1.6 g/kg bw) demonstrated a substantial neuroprotective effect against the metabolic abnormalities and oxidative stress generated by AlCl3 exposure. As a result, it can be inferred that date fruit consumption may be beneficial in the treatment of neurological illnesses and oxidative stress. At the same time ALCL3 exposure was linked to apoptotic and anti-apoptotic indicators, indicating free radical scavenging and significant antioxidant action. as well as the apoptotic and anti-apoptotic markers associated with AlCl 3 exposure revealing its powerful antioxidant and free radical scavenging properties. | ||
| Keywords | ||
| Date palm fruits (Phoenix Dactelifera L); Aluminum chloride; Neurotransmitters; Oxidative stress; Antioxidants; Apoptotic and anti-apoptotic markers | ||
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