The attenuating role of N-acetylcysteine in the haematological and antioxidant disruption induced by Atrazine in male rats | ||
| Mansoura Journal of Biology | ||
| Volume 58, Issue 5, December 2022, Pages 43-49 PDF (1.04 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456327 | ||
| Authors | ||
| Manar Ahmed Hussein Ali* ; Gamal Mohamed Fathy Edrees; Magda Mahmoud Arafa Elkomy. | ||
| Zoology department-Faculty of Science-Mansoura University | ||
| Abstract | ||
| The protective role of NAC against haematological abnormalities and disruption of antioxidant system in male rats given ATR was evaluated. Adult male rats orally receive ATR 200 mg/kg b.w. for 3 weeks, NAC 200 mg/kg b.w. or rats received NAC+ATR by the same dose for the same period. Rats given ATR showed significant decrease in RBCs count, Ht %, platelets count and neutrophile % in concomitant with increase in total WBCs count and lymphocyte %. Regarding the oxidative stress markers, there are increase in cardiac MDA, H2O2 as well as NO content, meanwhile cardiac GSH content and the activity of SOD and CAT declined. NAC significantly reconsider the haematological abnormalities and oxidant / antioxidant balance caused by ATR. It is concluded that, ATR induced cardiac damage via the enhancing of NO production and disrupt the hematopoietic functions, in addition to depletion of oxidant / antioxidant balance. | ||
| Keywords | ||
| NAC; ATR; Haematopoiesis; Antioxidants; ROS | ||
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