Role of N-acetyl cysteine in mitigates testicular abnormalities in male rats induced by Atrazine | ||
| Mansoura Journal of Biology | ||
| Volume 58, Issue 5, December 2022, Pages 58-64 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456330 | ||
| Authors | ||
| Asmaa Ayman Abosoliman Abosoliman* ; Gamal Mohamed fathy Edrees; Magda Mahmoud Arafa Elkomy | ||
| Zoology department, Faculty of science, Mansoura university | ||
| Abstract | ||
| The effect of N-acetyl cysteine (NAC) against Atrazine (ATR) on epididymal sperm characteristic in experimentally orally treated rats with a herbicide Atrazine was evaluated. Adult male albino rats exposed to 200 mg/kg ATR, 200 mg/kg NAC or their combination day by day for 3 weeks. In ATR treated group serum urea and uric acid are significantly exceeded compared to control. Epididymal sperm concentration, motility and vitality were declined, meanwhile the percentage of sperm abnormalities exceeded relative to control. Regarding oxidative stress markers, ATR caused increase in testicular contents of malondialdehyde (MDA) and nitric oxide (NO) in concomitant with decrease in activity of testicular antioxidants as SOD and CAT in addition to GSH content. The present result show the positive correlation between chronic kidney disease and epididymal sperm abnormalities which may be related to disturbance in antioxidant system, NAC with its antioxidant capacity suppress the adverse effect of ATR. | ||
| Keywords | ||
| Herbicides; Atrazine; NAC; Antioxidants | ||
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