Epileptic Patients Under Valproic Acid Assessment of Insulin Resistance and Cerebral Hemodynamics | ||
| International Journal of Medical Arts | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.384308.2184 | ||
| Authors | ||
| Reham Hamada Mohammed Mohammed* 1; Laila Elmously Naguib talaat2; Alshaymaa Mohammed Mahmoud Alhabibi3; Seham Elsaid Abdelsadek Abdelmohsen4 | ||
| 1Assistant lecturer of neurology, Neurology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
| 2Professor of neurology, Neurology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
| 3Assistant professor of clinical pathology, Clinical pathology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
| 4Assistant professor of neurology, Neurology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. | ||
| Abstract | ||
| Abstract Background This study investigates the impact of valproic acid (VPA) on insulin resistance (IR) and cerebral hemodynamics in epileptic patients. Methods This is a case-control study carried out on 90 participants aged 18-45 years (47 males, 43 females) between January 2023 and April 2024. Demographic, clinical, and anthropometric data were collected from all participants. IR was assessed using the Homeostasis Model Assessment (HOMA-IR) and asprosin, while cerebral hemodynamics were evaluated through Transcranial Color-Coded Duplex (TCCD) and Carotid Intima-Media Thickness (CIMT) measurements. Results The analysis revealed increase in Body Mass Index (BMI) and, weight in VPA group, were significantly higher in comparison to both the levetiracetam and control groups (p ≤ 0.001). The VPA group exhibited significantly higher fasting insulin levels (p ≤ 0.001), HOMA-IR values and asprosin compared to both the levetiracetam and control groups, indicating increased IR. TCCD selected parameters showed no significant differences among the groups. However, CIMT measurements were significantly increased in the VPA group (0.8 ± 0.2 mm) compared to the levetiracetam (0.5 ± 0.1 mm) and control groups (0.5 ± 0.1 mm) (p ≤ 0.001). Conclusion The findings suggest that VPA may contribute to increased IR, an atherogenic lipid profile characterized by elevated triglycerides and reduced HDL-cholesterol and abnormal CIMT supporting the need for careful monitoring of metabolic parameters and vascular ultrasound in this population. Keywords Valproic acid, epilepsy, HOMA-IR, TCCD, asprosin. | ||
| Keywords | ||
| Keywords Valproic acid; epilepsy; HOMA-IR; TCCD; asprosin | ||
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