Characterization of PDL1 Expression in High Grade Endometrial Carcinoma across the Spectrum of Tumor Stage and Patient Survival and Other Clinicopathological Features | ||
| Evidence Based Women's Health Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2025.426572.1515 | ||
| Authors | ||
| Malames Mahmoud Salama* 1; Ahmed Mahmoud Elhusainy2; Marwa Shakweer3; Esraa Elsayed4 | ||
| 1Obstetric and gynecology , faculty of medicine , ain Shams university | ||
| 2Faculty of medicine , ain shams university | ||
| 3Pathology department . Faculty of medicine ,ain shams university | ||
| 4Dr | ||
| Abstract | ||
| Objective: Evaluation of PDL1 immuno-histochemical expression in high grade endometrial carcinoma and its correlation with other known relevant variable clinical outcomes. Methods: This retrospective study was conducted on 38 women diagnosed as high grade endometrial carcinoma in the period from January 2014 till December 2018 with full medical records in Ain Shams University Oncology Hospital and in Early Cancer Detection Unit (ECDU) at Ain Shams University Hospital (ASUH). Patients' paraffin blocks were collected and tested for PDL1 expression using immunohistochemistry test (IHC) for detection of PDL1 proteins. Results: PD-L1 expression was reported in 44.7% (n: 17) versus 55.3% (n: 21) without expression and PD-L1 TIL expression in 28.9% (n: 11) versus 71.1% (n: 27) without expression with no statistical significant relation. No significant relationship was noted between PD-1 and PD-L1 expressions and tumor histological type, size, endometrial invasion, lympho-vascular invasion, tumor margins, surgical FIGO staging and tumor metastasis. No correlation was noted between PD-L1 and PD-L1 TIL expression and recurrence and mortality rates. According to our knowledge there was no previous studies evaluated these parameters. Conclusion: No difference was reported of PDL1 expression between early and late stages of high grade endometrial cancer and its immunohistochemically expression hadn’t prognostic value in high grade tumor and its correlation to progression free survival (PFS) and overall survival (OS). | ||
| Keywords | ||
| Cancer endometrium; tumour; prognosis | ||
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