Helicobacter Pylori Infection and Childhood Atopic Asthma | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 October 2025 PDF (678.76 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.403763.2539 | ||
| Authors | ||
| Iman A. Ali1; Maha T. Rashwan2; Samar A. Metawaa* 3; Ahmed A. Sobeih4 | ||
| 1Professor of Pediatrics, Faculty of Medicine, Benha University | ||
| 2Lecturer of Clinical Pathology, Faculty of Medicine, Benha University | ||
| 3M.B.B.Ch, Faculty of Medicine, Benha University | ||
| 4Assistant Professor of Pediatrics, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: An asthmatic condition is characterized by the chronic inflammation of the airways. Helicobacter pylori (H. pylori) infection has been linked to gastroduodenal disease. An inverse correlation between H. pylori infection and asthma or asthma-related conditions has been evidenced by a multitude of epidemiological investigations, particularly those conducted on minors. This study aimed to assess the correlation between infantile asthma and H. pylori infection. Methods: This cross-sectional study included 114 participants (57 children who were diagnosed as bronchial asthma and 57 children age and sex matched as a control group) at Pediatric chest and allergy clinic of Benha University Hospitals. Participants underwent investigation including complete blood count, total serum immunoglobulin E (IgE) and detection of H. Pylori antigen. Results: Asthma did not exhibit any correlation with H. pylori infection. There was a significant positive correlation between serum IgE and H. pylori infection. Conclusion: Our results suggest that asthma in a first-degree relative, family history of asthma, day care attendance, and the presence of comorbidities have statistically significant associations with asthma, highlighting their potential function as risk factors. Also, serum IgE levels, eosinophil counts, and the presence of H. pylori infection were significantly different, suggesting a possible immunologic component. There was, however, no direct correlation between the presence or severity of asthma and H. pylori infection. Elevated serum IgE and H. pylori infection are significantly positively correlated, which implies a potential association with systemic allergic sensitization. | ||
| Keywords | ||
| Helicobacter Pylori; Infection; Childhood Atopic Asthma; Immunoglobulin E | ||
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