Exploring Egyptian Ecosystems for Bioactive Actinomycetes: A Review of Diversity and Therapeutic Potential | ||
| AlSalam International Journal of Pharmacy | ||
| Volume 2, Issue 1, September 2025, Pages 44-65 PDF (522.39 K) | ||
| Document Type: Scientific review | ||
| DOI: 10.21608/aijp.2025.411461.1008 | ||
| Authors | ||
| Randa Hesham Khattab* ; Rana Adel El-Nagar | ||
| Microbiology and Immunology, Faculty of Pharmacy, Alsalam Universit | ||
| Abstract | ||
| Actinomycetes are a prolific group of gram-positive filamentous bacteria known for producing a wide array of bioactive secondary metabolites with crucial pharmaceutical applications. These include antibiotics, anticancer agents, antifungals, and antiparasitic compounds. While the genus Streptomyces has been extensively studied on a global scale, actinomycetes from certain ecological regions remain poorly investigated. Egypt, characterized by its diverse ecosystems—including deserts, marine environments, freshwater sources, and cultivated lands—offers a largely untapped reservoir of actinomycete diversity. This review compiles and analyzes recent findings on actinomycetes isolated from various Egyptian ecosystems, focusing on their taxonomy and the biological activities of their metabolites. Emphasis is placed on compounds showing antibacterial, antifungal, antitumor, and other pharmacologically important properties. The promising therapeutic potential of these microorganisms highlights the importance of continued exploration within Egypt’s varied habitats. This work encourages further research to discover novel actinomycetes and unlock their potential as sources of innovative therapeutic agents addressing global health challenges. | ||
| Keywords | ||
| Actinomycetes; Streptomyces; Egypt; microbial diversity; secondary metabolites | ||
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