Evaluation of Candida colonization in the oral cavity of diabetic and non-diabetic patients. | ||
| Mansoura Journal of Biology | ||
| Volume 59, Issue 6, December 2022, Pages 22-25 PDF (951.36 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456506 | ||
| Authors | ||
| Eman Abd Elhady ELMekawy* 1; Gamal M. Abdel-Fattah1; Ahmed M. ELBehiry2; RashaMokhtar Elnagar3 | ||
| 1Microbiology and Botany Department, Faculty of science, Mansoura university, Mansoura, Egypt. | ||
| 2Diabetes and Endocrinology unit, Faculty of Medicine, Mansoura university, Mansoura, Egypt | ||
| 3Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura university, Mansoura, Egypt | ||
| Abstract | ||
| Candida is found as normal microflora in the oral cavity, skin, gastrointestinal tract, and vagina in healthy people. However, when the mucosal barrier is disrupted, or the immune system compromised it changes into a pathogen and cause infection. OC is the common infection that occur in the oral cavity as a result of an overgrowth of Candida especially C.albician. There are numerous risk factors as: age, gender, nutrition, smoking, denture, oral hygiene, salivary pH illness and xerostomia (dry mouth) that make diabetic patients more susceptible to OC. Diabetes mellitus is a common endocrine metabolic disorder in which high glucose level of saliva, low secretion of saliva, xerostomia and disruption of physiological conditions promote the overgrowth of Candida and cause infections. Sixty-seven isolates were collected from a patient admitted to Specialized Medical Hospital, In Mansoura. Forty –two isolates were belong to diabetic patients while the last fifteen were from normal healthy people as a control. The isolates were cultured on SDA then identified morphologically and gram staining. The identification with different species latterly done by Germ tube test (rapid identification of C.albician) and then VITEK. In germ tube test, 52 isolates show identical C.albician, while the last 15 then later identified by VITEK in which 11 isolates were C.albician, 1 C.Keurosi, 1 C.tropicalis, and 2 C.dublinisis.The most dominant specie was C.albican which represent 83% of isolates. | ||
| Keywords | ||
| Candida; Oral candidiasis (OC); C.albician; Diabetes mellitus (DM) | ||
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