In vitro efficacy of antifungal activities either singly or loaded on nanomaterials, as new and novel drug delivery systems on the growth of Alternaria alternata and Botrytis fabae fungal pathogens | ||
| Mansoura Journal of Biology | ||
| Volume 59, Issue 6, December 2022, Pages 54-61 PDF (1.22 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456543 | ||
| Authors | ||
| Sara H. Helal1; Mohammed N. A. Hasaneen1; Mustafa M. El-Zayat2; Heba M. M. Abdel- Aziz2 | ||
| 1Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| 2Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt. | ||
| Abstract | ||
| The present study aims to search for a novel nano-drug delivery systems through carrying out in vitro experiment that enables access of antifungal antibiotics to the targeting site of the fungal pathogens. To achieve this target, two antifungals; nystatin (NYS) and fluconazole (FLZ), were loaded on three different nanomaterials; chitosan nanoparticles (CSNPs), carbon nanotubes (CNTs) and solid lipid nanoparticles (SLNPs) to facilitate drug delivery to the fungal pathogens (Alternaria alternata and Botrytis fabae). The nano drug delivery systems were evaluated by determination of the efficient antifungal activity on the fungal pathogens comprising the tested drug delivery systems. The results obtained revealed that the tested strains were resistant to sole nanomaterials (CSNPs, CNTs and SLNPs) and sensitive to the loaded nanomaterials with either nystatin or fluconazole antifungals. The efficiency of the tested three drug delivery systems revealed that loaded solid nanoparticles (SLNPs) were the most efficient nano drug delivery systems for controlling the two fungal pathogens | ||
| Keywords | ||
| antifungals; fungi; nanomaterials; nystatin | ||
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