Protective and Therapeutic Effects of Astragalus membranaceus on CCl₄-Induced Nephrotoxicity in Rats | ||
| مجلة بحوث التربية النوعية | ||
| Volume 2025, Issue 96, October 2025 | ||
| Document Type: مقالات علمیة محکمة | ||
| DOI: 10.21608/mbse.2025.403254.1662 | ||
| Authors | ||
| ايمان محسن حلمي زعلوك* 1; أسامة ابراهيم النحاس2; فايزه الازلي1 | ||
| 1كليه التربيه النوعيه جامعه المنصوره | ||
| 2کلية التربية النوعية جامعة المنصورة | ||
| Abstract | ||
| Kidney failure is a progressive disorder linked to oxidative stress, impaired filtration, and inflammation. This study evaluated the therapeutic effects of Astragalus membranaceus (AM), in powder and aqueous extract forms, on carbon tetrachloride (CCl₄)-induced kidney dysfunction in rats. Twenty-four adult male Wistar rats (110 ± 10 g) were divided into four groups (n=6): a negative control group fed a basal diet, and three CCl₄-injected groups—positive control, AM powder-treated (5% in diet), and AM aqueous extract-treated (1:10 w/v, 7.5 mL/100 g/day for 28 days). CCl₄ caused significant reductions in body weight, weight gain, feed intake, and feed efficiency, alongside elevated serum urea, creatinine, uric acid, ALT, AST, oxidative stress markers (MDA, H₂O₂), and CRP, with reduced antioxidant enzymes (CAT, SOD, GSH, GPx) and electrolyte imbalance. Treatment with AM, especially in powder form, significantly improved all parameters: kidney function markers normalized, antioxidant enzyme activities increased, liver enzymes (ALT, AST) decreased, and electrolyte balance was restored. The powder form showed slightly superior effects compared to the aqueous extract. A sensory evaluation of AM aqueous extract (5%, 10%, 15%) revealed that the 5% and 10% concentrations were most acceptable, while the 15% was less preferred due to bitterness. In conclusion, Astragalus membranaceus—in both forms—exhibited strong protective effects against kidney dysfunction, with powdered AM showing slightly better therapeutic outcomes. It is recommended as a functional supplement for promoting kidney and liver health. | ||
| Keywords | ||
| Kidney dysfunction; Herbal medicine; Carbon Tetrachloride (CCl₄) and experimental rats | ||
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