A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C
G., S., W., S., S., S., A, E., M., E., R., S., A., M., K., Z. (2016). A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C. EKB Journal Management System, 1.2(2), 1-10. doi: 10.21608/mjvh.2016.4567
Shiha G.; Samir W.; Seif S.; Eldesoky A; Elbasiony M.; Soliman R.; Metwally A.; Zalata K.. "A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C". EKB Journal Management System, 1.2, 2, 2016, 1-10. doi: 10.21608/mjvh.2016.4567
G., S., W., S., S., S., A, E., M., E., R., S., A., M., K., Z. (2016). 'A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C', EKB Journal Management System, 1.2(2), pp. 1-10. doi: 10.21608/mjvh.2016.4567
G., S., W., S., S., S., A, E., M., E., R., S., A., M., K., Z. A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C. EKB Journal Management System, 2016; 1.2(2): 1-10. doi: 10.21608/mjvh.2016.4567

A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-severe and severe fibrosis in patients with chronic Hepatitis C

Medical Journal of Viral Hepatitis
Article 2, Volume 1.2, Issue 2, June 2016, Pages 1-10    PDF (188.64 K)
Document Type: Original article
DOI: 10.21608/mjvh.2016.4567
Authors
Shiha G.1; Samir W.2; Seif S.1; Eldesoky A1; Elbasiony M.1; Soliman R.3; Metwally A.4; Zalata K.5
1Gastrohepatology Unit, Internal Medicine dept., Faculty of Medicine, Mansoura Univ., Egypt.
2Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt
3Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt.
4Community Medicine Department, National Research Center, Cairo, Egypt
5Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
Abstract
A simple noninvasive score (Fibrofast, FIB-5) was developed using five routine laboratory tests (ALT, AST, Alkaline phosphatase, Albumin and Platelets count) for the detection of severe hepatic fibrosis in patients with chronic hepatitis C. The FIB-4 index is a noninvasive test for the assessment of liver fibrosis, and a score of ≤3.35 enables the correct identification of patients who have nonsevere (F0-2) from severe fibrosis (F3 4), and could avoid liver biopsy. The aim of this study was to compare the performance characteristics of FIB-5 and FIB-4 to differentiate between nonsevere
from severe fibrosis. A cross-sectional study included 604 chronic HCV patients. All liver biopsies were scored using
METAVIR system. Both FIB-5 and FIB-4 scores were measured and the performance characteristics were calculated using the ROC curve. The performance characteristics of Fibro-Fast at ≥ - 2.1 and FIB-4 at ≤ 3.25 for the differentiation between non-severe fibrosis and severe fibrosis were; sensitivity 39.6%, NPV 88.7% and sensitivity 29.7%, NPV 87.4% respectively. Conclusion: FIB-5 score at the new cutoff is more superior to FIB-4 index for the differentiation between non- severe and severe fibrosis. 
Keywords
Fibrofast (FIB-5); FIB-4; Liver fibrosis; Liver Biopsy; Hepatitis C Genotype 4
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